慢性阻塞性肺疾病急性加重患者血清GGT水平与炎症因子及肺功能的关系

Relationship between serum GGT level with inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease

目的探讨慢性阻塞性肺疾病急性加重期(AECOPD)患者血清γ-谷氨酰转肽酶(GGT)水平与炎症因子及肺功能的关系。方法选取2017年1月—2019年12月于安徽省芜湖市第二人民医院(以下简称“我院”)随诊的AECOPD患者103例(AECOPD组),依据患者入院时GGT均值分为高GGT组(>63.59 U/L,41例)和低GGT组(≤63.59 U/L,62例)。另选慢性阻塞性肺疾病稳定期(SCOPD)患者92例(SCOPD组)和体检健康者80例(CON组)作为对照。分析AECOPD组、SCOPD组、CON组的临床资料、GGT、炎症因子及肺功能的差异,比较不同GGT水平下AECOPD患者炎症因子及及肺功能的差异,分析AECOPD患者血清GGT水平与炎症因子及肺功能的相关性。结果AECOPD组和SCOPD组血清降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、GGT水平高于CON组,第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC低于CON组,差异有统计学意义(P<0.05)。AECOPD组血清PCT、CRP、IL-6、GGT水平高于SCOPD组,FVC、FEV1、FEV1/FVC低于SCOPD组,差异有统计学意义(P<0.05)。高GGT组PCT、CRP、IL-6水平高于低GGT组,而FVC、FEV1、FEV1/FVC低于低GGT组(P<0.05)。AECOPD患者血清GGT水平与PCT、CRP、IL-6均呈显著正相关(r=0.706、0.802、0.589,P<0.001),与FEV1、FVC及FEV1/FVC均呈显著负相关(r=-0.562、-0.657、-0.734,P<0.001)。结论AECOPD患者血清GGT水平明显升高,与炎症因子和肺功能具有较好的相关性,可为患者炎症反应及肺功能的评估提供帮助。

Objective To investigate the relationship between serum levels ofγ-glutamyl transferase(GGT)with inflammatory factors and lung function in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods One hundred and three patients with AECOPD were followed up in the Second People′s Hospital of Wuhu City in Anhui Province(“our hospital”for short)from January 2017 to December 2019 were selected as AECOPD group,they were divided into high GGT group(>63.59 U/L,41 cases)and low GGT group(≤63.59 U/L,62 cases)according to the average GGT at admission.In addition,92 patients with stable of chronic obstructive pulmonary disease(SCOPD)patients(SCOPD group)and 80 healthy people(CON group)were selected as control.The differences of general clinical data,GGT,inflammatory factors and lung function between AECOPD group,SCOPD group and CON group were analyzed,and the differences of inflammatory factors and lung function in AECOPD patients with different GGT levels were compared,and the correlation between serum GGT level and inflammatory factors and lung function in AECOPD patients was analyzed.Results The levels of serum procalcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)and GGT in AECOPD group and SCOPD group were higher than those in CON group,FVC,FEV1 and FEV1/FVC in AECOPD group and SCOPD group were lower than those in CON group(P<0.05).The levels of PCT,CRP,IL-6 and GGT in AECOPD group were higher than those in SCOPD group,and FVC,FEV1,FEV1/FVC in AECOPD group were lower than those in SCOPD group(P<0.05).The levels of PCT,CRP and IL-6 in high GGT group were higher than those in low GGT group,while FVC,FEV1 and FEV1/FVC in high GGT group were lower than those in low GGT group(P<0.05).The level of serum GGT was positively correlated with PCT,CRP and IL-6(r=0.706,0.802,0.589,P<0.001),and negatively correlated with FEV1,FVC and FEV1/FVC(r=-0.562,-0.657,-0.734,P<0.001).Conclusion The serum GGT level in AECOPD patients is significantly increased,which has a good correlation with inflammatory factors and lung function,and can provide help for the evaluation of inflammatory response and lung function in patients.