内分泌治疗激素受体阳性乳腺癌的效果及其与ESR1基因位点的关系

Effect of endocrine therapy on hormone receptor positive breast cancer and its relationship with ESR1 gene locus

目的研究内分泌治疗激素受体阳性乳腺癌的效果及其与雌激素受体1基因(ESR1)单核苷酸多态性位点(rs2077647和rs3798759)的关系。方法选择2014年1月—2018年12月于江苏省常熟市第五人民医院收治的86例激素受体阳性乳腺癌患者为研究对象,均接受内分泌治疗,并接受ESR1单核苷酸多态性位点(rs2077647和rs3798759)检测。分析内分泌治疗后短期疗效,并观察其与ESR1单核苷酸多态性位点的关系。结果86例患者内分泌治疗后完全缓解、部分缓解、疾病稳定共45例,均归入ETR组;疾病进展41例,归入ETNR组。ETR组rs2077647位点基因型为CC型者占比显著高于ETNR组(P<0.05),rs3798759位点基因型为TT型者占比显著低于ETNR组(P<0.05),且基因型为TG型者占比显著高于ETNR组(P<0.05)。ETR组rs2077647位点等位基因为C者占比显著高于ETNR组(P<0.05),rs3798759位点等位基因为G者占比显著高于ETNR组(P<0.05)。ESR1基因多态性是患者内分泌治疗效果的独立影响因素(P<0.05)。结论内分泌治疗激素受体阳性乳腺癌后疗效与ESR1单核苷酸多态性位点(rs2077647和rs3798759)密切相关。

Objective To study the effect of endocrine therapy on hormone receptor positive breast cancer and its relationship with ESR1 gene locus(rs2077647 and rs3798759).Methods Eighty-six patients with hormone receptor positive breast cancer admitted to the Fifth People′s Hospital of Changshu City in Jiangsu Province from January 2014 to December 2018 were selected as study objects.All patients were treated with endocrine therapy and ESR1 single nucleotide polymorphisms(rs2077647 and rs3798759)were detected.The short-term efficacy of endocrine therapy was analyzed and its relationship with ESR1 single nucleotide polymorphisms was observed.Results Forty five patients of 86 patients with complete remission,partial remission and stable disease after endocrine therapy were included in ETR group,41 patients with disease progression were classified into ETNR group.The proportion of genotype CC at rs2077647 in ETR group was significantly higher than that in ETNR group(P<0.05),the proportion of TT genotype of rs3798759 was significantly lower than that of ETNR group(P<0.05),and the proportion of TG genotype was significantly higher than that of ETNR group(P<0.05).The proportion of allele C at rs2077647 in ETR group was significantly higher than that in ETNR group(P<0.05),and the proportion of allele G at rs3798759 was significantly higher than that in ETNR group(P<0.05).ESR1 gene polymorphism was an independent factor affecting the effect of endocrine therapy(P<0.05).Conclusion The effect of endocrine therapy on hormone receptor-positive breast cancer is closely related to ESR1 single nucleotide polymorphisms(rs2077647 and rs3798759).