多索茶碱与氨茶碱治疗老年慢性阻塞性肺疾病的疗效比较

Comparative Analysis of Effects of Doxofylline and Aminophylline in the Treatment of Chronic Obstructive Pulmonary Disease in the Elderly

目的比较多索茶碱与氨茶碱治疗老年慢性阻塞性肺疾病(C0PD)的疗效。方法选取2018年1月至2019年1月在海南省万宁市人民医院呼吸内科治疗的88例老年C0PD患者,按随机数字法分为观察组和对照组,每组44例,均给予常规药物治疗。在此基础上,对照组使用氨茶碱治疗,观察组使用多索茶碱治疗。比较两组患者的临床疗效、肺功能及血气分析指标、血清炎性指标及不良反应发生率。结果观察组治疗有效率明显高于对照组(93.18%vs.72.73%,P<0.05);治疗后观察组第1 s用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC及血氧分压(Pa02)明显高于对照组,二氧化碳分压(Pa%)明显低于对照组(P<0.05);观察组血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)、白介素-8(IL-8)、白介素-18(IL-18)水平明显低于对照组(P<0.05);观察组恶心、咽喉不适、口干、胃肠道不适等不良反应发生率明显低于对照组(P<0.05)。结论多索茶碱治疗老年C0PD的疗效更佳,对改善肺功能及血气分析指标效果更为明显,有效提升了肺通气功能,改善机体低氧血症,并促进炎性因子的消退。

Objective To compare the effects of doxofylline and aminophy 11 ine in the treatment of elderly patients with chronic obstruetive pulmonary disease(C0PD).Methods From January 2018 to January 2019,88 elderly patients with COPD were randomLy divided into observation group and control group,44 cases in each group.All patients were given routine drug treatment,on this basis,the control group was treated with aminophylline,the observation group was treated with doxofylline.The clinical effects,pulmonary function,blood gas analysis index,serum inflammatory index,and incidence of adverse reactions were compared between the two groups.Results The effective rate of treatment in the observation group was significantly higher than the control group(93.18%vs.72.73%,P<0.05).After treatment,FEV1,FVC,FEV1/FVC and Pa02 in the observation group were significantly higher than those in the control group,and PaC02 was significantly lower than that in the corrtrol group(P<0.05).After treatment,the serum levels of hs-CRP,TNF-α,IL-8 and IL-18 in the observation group were significantly lower than those in the control group(P<0.05).The incidence of adverse reactions such as nausea,throat discomfort,dry mouth and gastrointestinal discomfort in the observation group was significantly lower than that in the control group(P<0.05).Conclusion Doxofylline was more effective in thw treatment of elderly patients with COPD,which can effectively improve lung function,blood gas analysis indexes,pulmonary ventilation function,and hypoxemia,and promote the regression of inflammatory factors.