含硒动态共价高分子

Selenium-containing Dynamic Covalent Polymers

动态共价键是一种在外界刺激下能够发生断裂、生成、重组的特殊化学键,它们在自修复材料、形状记忆材料等动态高分子的研究中扮演重要角色.我们课题组近年系统地研究了一系列具有不同响应特征的含硒动态共价键家族,包括可见光响应的Se-Se键和Se-Te键、紫外光响应的Se-S键以及超声响应的Se-N键等.将这些含硒动态键引入高分子中可以赋予材料一系列独特的动态特征.本文总结了我们课题组在含硒动态共价高分子领域的研究工作,从一系列具有不同结构和刺激响应特征的含硒动态键出发,随后介绍它们在高分子材料中的应用.例如,基于可见光响应的二硒动态交换反应,含二硒键的高分子材料可以在可见光照射下实现远程自修复、形状记忆、光塑性以及信息存储等功能.利用高分子材料在溶剂中溶胀力和应力松弛的平衡,可以实现含二硒键聚氨酯的三维图案化.除了体相高分子材料外,含硒动态共价高分子还可应用于生物医用材料领域.我们设计了一种含有Se-N键的高分子组装体,基于含硒、硫动态键的相互转化,该组装体表现出良好的抗癌活性.

The dynamic covalent bond(DCB)is a kind of special bond that can cleave,reform,and exchange under external stimulus.DCBs have been evolved in a wide range of polymers like self-healing materials,shape memory materials and so on.Selenium is an essential element in human bodies.Our research group pioneered in the research of Se-containing dynamic polymers,and discovered that many Se-containing bonds are dynamic covalent bonds with very mild responsive conditions due to selenium’s unique chemical properties.This feature article is aimed to summarize the recent progress in the field of selenium-containing dynamic covalent bonds and their applications in dynamic polymeric materials.We started from the discovery of several Se-containing DCBs and the introduction of their distinct responsive features,including visible light responsive Se-Se bond and Se-Te bond,UV light responsive Se-S bond and sonication responsive Se-N bond.Then we exhibited how integrating Se-containing DCBs into polymers could produce dynamic features in materials.For instance,based on the visible light responsive diselenide dynamic exchange reaction,the diselenide bond containing polymers can achieve remote self-healing,shape memory,light plasticity and information storage.By employing the balance of swelling and strain relaxation for polymers in solvent,diselenide bond containing polyurethane could achieve 3D patterning.Apart from dynamic bulk materials,selenium-containing polymer could also serve as biomaterials.We designed a Se-N bond containing polymer assembly,which showed impressive anti-cancer effect via the transformation of Se,S based DCBs.