盐酸氨溴索注射液联合雾化吸入治疗急性加重期慢性阻塞性肺疾病临床研究

Clinical study of ambroxol hydrochloride injection combined with aerosol inhalation in the treatment of acute aggravation chronic obstructive pulmonary disease

目的:探讨雾化吸入联合盐酸氨溴索治疗急性加重期慢性阻塞性肺疾病(AECOPD)的临床效果。方法:2019年2月-2019年12月收治AECOPD患者100例,随机分为两组,各50例。对照组给予解痉平喘、祛痰、持续低流量吸氧、抗感染等常规治疗;观察组在常规治疗基础上给予盐酸氨溴索注射液联合雾化吸入治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,各项症状消失时间均短于对照组,差异均有统计学意义(P<0.05)。观察组治疗后肺功能及动脉血气各项指标水平均明显优于对照组,差异有统计学意义(P<0.05)。结论:盐酸氨溴索注射液联合雾化吸入治疗AECOPD患者,可明显改善临床症状,疗效显著。

Objective:To investigate the clinical effect of aerosol inhalation combined with ambroxol hydrochloride in the treatment of acute exacerbation chronic obstructive pulmonary disease.Methods:From February 2019 to December 2019,100 cases of patients with acute exacerbation chronic obstructive pulmonary disease(AECOPD)were enrolled,they were randomly divided into two groups with 50 cases in each group.The control group was given conventional treatment such as antispasmodic asthma,expectoration,continuous low-flow oxygen inhalation and anti-infection.The observation group was treated with ambroxol hydrochloride injection combined with ambroxol hydrochloride on the basis of conventional treatment.The therapeutic effects between the two groups was compared.Results:The total effective rate of treatment in the observation group was higher than that in the control group and the time of symptom disappearance was shorter than that in the control group,the differences were statistically significant(P<0.05).After treatment,the various of indicator levels of pulmonary function and arterial blood gas in observation group were better than those in control group,the differences were statistically significant(P<0.05).Conclusion:Ambroxol hydrochloride injection combined with ambroxol hydrochloride can obviously improve the clinical symptoms in patients with acute exacerbation chronic obstructive pulmonary disease and it has a significant effect.