急性ST段抬高型心肌梗死患者血清Apelin、基质金属蛋白酶9和肌钙蛋白Ⅰ水平及意义

The levels and significance of serum Apelin,matrix metalloproteinase-9 and cardiac tropnin Ⅰ in patients with acute ST segment elevation myocardial infarction

目的:探讨急性ST段抬高型心肌梗死(STEMI)患者血清Apelin、基质金属蛋白酶9(MMP-9)和肌钙蛋白I(cTnI)水平及临床意义。方法:选取2018年1月-2019年9月STEMI患者66例,作为观察组。另选取同期体检正常者50例,作为对照组。检测两组血清Apelin、MMP-9及cTnI水平。结果:观察组血清Apelin水平明显低于对照组,血清MMP-9、cTnI水平明显高于对照组,差异有统计学意义(P<0.05)。结论:Apelin和MMP-9参与STEMI的发病,与cTnI一样可以作为STEMI的诊断依据,Apelin有望成为冠心病治疗的一个新靶点。

Objective:To explore the levels and significance of serum Apelin,matrix metalloproteinase-9(MMP-9)and cardiac tropnin I(cTnI)in patients with acute ST segment elevation myocardial infarction.Methods:From January 2018 to September 2019,66 patients with acute ST segment elevation myocardial infarction(STEMI)were selected as the observation group.Another 50 cases with normal physical examination were selected as the control group.The serum levels of Apelin,MMP-9 and cTnI in the two groups were detected.Results:In the observation group,the serum Apelin level was significantly lower than that of the control group,and the serum MMP-9 and cTnI levels were significantly higher than those of the control group,the difference was statistically significant(P<0.05).Conclusion:Apelin and MMP-9 are involved in the pathogenesis of STEMI,like cTnI,Apelin can be used as a diagnostic basis for STEMI,Apelin is expected to become a new target for the treatment of coronary heart disease.