卵巢低反应患者实施卵泡期联合黄体期促排卵对妊娠活产率和卵巢反应性的影响分析

Effect of follicular phase combined with luteal phase ovulation induction on the pregnancy live birth rate and ovarian response in patients with low ovarian response

目的分析卵泡期+黄体期促排卵方案对卵巢低反应患者妊娠活产率及卵巢反应性的影响。方法选取2016年2月至2019年1月黄石市第五医院诊治的86例卵巢低反应患者资料作回顾性分析。根据促排卵方案不同分为两组,研究组(n=35)为卵泡期+黄体期促排卵干预方案,对照组(n=51)为单行卵泡期微刺激促排卵干预方案。对比两组患者获卵数、获卵率等促排卵情况及受精结局、临床妊娠结局,综合评估患者卵巢反应性。结果研究组患者扳机日P与E2水平明显高于对照组患者,LH水平低于对照组患者,且研究组患者平均获卵数、可用胚胎数多于对照组患者,差异均具有统计学意义(均P<0.05);两组患者获得优质胚胎率及成功受精率、异位妊娠率比较,差异无统计学意义(P>0.05);研究组患者周期取消率低于对照组患者,且临床妊娠率、活产率高于对照组患者,差异具有统计学意义(P<0.05)。结论卵泡期+黄体期促排卵干预可调控患者HCG注射扳机日雌激素水平,改善排卵受精情况,提升卵巢反应性,并可显著提升患者临床妊娠率及活产率,值得推广。

Objective To analyze the effect of ovulation induction in the follicular phase and luteal phase on the pregnancy live birth rate and ovarian response in patients with low ovarian response.Methods 86 patients with ovarian hyporesponsiveness received in Huangshi Fifth Hospital from February 2016 to January 2019 were retro-spectively analyzed.According to the ovulation induction program,they were divided into the control group(n=51)and the study group(n=35).The control group received single-line follicular micro-stimulation ovulation induction intervention and the study group received follicular phase and luteal phase ovulation induction intervention.The number of eggs,egg-obtained rate and other ovulation induction and fertilization outcomes and clinical pregnancy outcomes were compared between the two groups,and comprehensive assessment of ovarian response was performed.Results The P and E 2 levels in the study group were significantly higher than those in the control group,the LH level was lower and the average number of eggs and available embryos in the study group were higher than those in the control group,all with statistically significant differences(P<0.05).There was no significant difference in the quality embryo rate,successful fertilization rate and ectopic pregnancy rate between the two groups(P>0.05).The cycle cancellation rate of the study group was lower than that of the control group,and the clinical pregnancy rate and live birth rate were higher than those in the control group,with statistically significant differences(P<0.05).Conclusions Follicular phase and luteal phase ovulation induction can regulate the estrogen level on HCG injection trigger day,improve ovulation and fertilization,ovarian response,and the clinical pregnancy rate and live birth rate,which is worth promoting.