辅助生殖技术助孕产妇产后出血的临床研究

Clinical study of postpartum hemorrhage in pregnancies through assisted reproductive technology

目的探讨辅助生殖技术与助孕产妇的产后出血的相关性。方法选取2014年1月至2018年1月安徽省妇幼保健院生殖中心接受辅助生殖技术治疗且最终在安徽省妇幼保健院单胎分娩的405例患者作为研究对象。将这405例研究对象设为助孕组,以同时期在安徽省妇幼保健院单胎分娩的571例自然受孕者作为对照组。分组比较产妇产后出血结局。结果助孕组产妇和对照组产妇在自身年龄、体重、体重指数及胎儿体重上比较,差异无统计学意义(P>0.05);助孕组产妇剖宫产率较对照组产妇剖宫产率明显升高,差异具有统计学意义(P<0.05);助孕组产妇产后出血发生率较对照组产妇明显升高,差异具有统计学意义(P<0.05);在助孕组内,阴道分娩组产妇产后出血发生率较剖宫产组产妇产后出血发生率明显升高,差异具有统计学意义(P<0.05)。结论单胎分娩时,辅助生殖技术助孕者产后出血发生率较自然妊娠者高,且助孕组分娩时阴道分娩组产后出血发生率高于剖宫产组。

Objective To retrospectively analyze the postpartum hemorrhagic(PPH)outcome in 405 pregnancies through assisted reproductive technology(ART)and to further explore the correlation.Methods A total of 405 women who received ART in the Reproductive Center of Anhui Women and Child Health Care Hospital from January 2014 to January 2018 and finally singleton delivered in the hospital were enrolled in this study.They were assigned as the ART group.Another 571 cases of natural pregnancy in our hospital during the same period served as the control group.The PPH outcomes were compared between the two groups.Results There was no difference in the average age,body weight,BMI and fetal weight between the two groups(P>0.05).The ART group had significantly higher rate of cesarean section than the control group,with statistically significant differences(P<0.05),and obviously higher incidence of PPH,with statistically significant differences(P<0.05).In the ART group,the vaginal delivery subgroup had significantly higher incidence of PPH than the cesarean section subgroup,with statistically significant differences(P<0.05).Conclusions The incidence of PPH is higher in the ART group than that in the control group and in the ART group,the vaginal delivery subgroup has significantly higher incidence of post-partum hemorrhage than the cesarean section subgroup.