聚苯胺负载铜催化嘧啶-2-胺的Buchwald-Hartwig偶联反应

Polyaniline-Supported Copper-Catalyzed Buchwald-Hartwig Couplings of Pyrimidin-2-amines

Buchwald-Hartwig偶联反应可用于嘧啶-2-胺的修饰.由于嘧啶-2-胺结构在药物中广泛存在,该反应有重要的工业应用价值.聚苯胺负载铜催化剂可由苯胺在铜盐存在下氧化聚合来合成,该催化剂可催化嘧啶-2-胺的Buchwald-Hartwig偶联反应.由于聚苯胺载体上氮本身就具有配位性能,该反应无需添加额外配体,即可以较高转化数(TON)催化反应.作为非均相催化剂,聚苯胺负载铜可回收利用,从而显著降低催化剂成本,符合工业应用需求.

Buchwald-Hartwig couplings can modify the pyrimidin-2-amines.Since the pyrimidin-2-amine structures widely exist in medicines,the reaction is of significant industrial application values.The polyaniline-supported copper catalyst(Cu@PANI)was synthesized via the oxidative polymerization of aniline in the presence of copper salt and it could catalyze the Buchwald-Hartwig couplings of pyrimidin-2-amines.Since the nitrogen in polyaniline could well coordinate with copper,the reaction did not require additional ligands and occurred at relatively high catalyst turnover numbers(TONs).As a heterogeneous catalyst,Cu@PANI could be recycled and reused to reduce the cost of catalyst,and meet the requirements of industrial application.