益生菌联合美沙拉嗪对轻度活动期溃疡性结肠炎的疗效观察

Observation of clinical efficacy of probiotics combined with mesalazine on the mild active ulcerative colitis

目的:分析益生菌联合美沙拉嗪治疗溃疡性结肠炎的临床疗效。方法:2018年7月-2019年9月收治轻度活动期溃疡性结肠炎患者50例,随机分为两组,各25例。对照组给予美沙拉嗪治疗;观察组给予益生菌联合美沙拉嗪治疗。比较两组治疗效果。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后症状积分及炎症因子水平均优于对照组,差异有统计学意义(P<0.05)。结论:采用益生菌联合美沙拉嗪治疗溃疡性结肠炎,能提高治疗总有效率,改善炎症因子水平,且不良反应少,安全性高。

Objective:To analyze the clinical efficacy of probiotics combined with mesalazine in the treatment of ulcerative colitis.Methods:From July 2018 to September 2019,50 patients with mild active ulcerative colitis were selected,and they were randomly divided into the two groups with 25 cases in each group.The control group was treated with mesalazine.The observation group was treated with probiotics combined with mesalazine.The therapeutic effects between the two groups was compared.Results:The total effective rate of treatment in the observation group was higher than the control group,with the difference was statistically significant(P<0.05).After treatment,symptom integral and the level of inflammatory factors in the observation group were all better than the control group,with the differences were statistically significant(P<0.05).Conclusion:Probiotics combined with mesalazine in the treatment of ulcerative colitis can improve the total effective rate of treatment,improve the level of inflammatory factors,which have less adverse reactions and high safety.