紫草素及其衍生物抗妇科肿瘤作用研究进展

Research progress of anti-gynoecological tumors effect of shikonin and its derivatives

紫草素是从传统中药紫草中提取的萘醌类化合物,具有抗炎、抗氧化、抗肿瘤、促进伤口愈合等作用。近年来,紫草素及其衍生物的抗肿瘤作用得到广泛研究。多项体外和体内研究表明紫草素及其衍生物可有效抑制乳腺癌、宫颈癌等妇科恶性肿瘤的发生与发展。从阻滞细胞周期、促进肿瘤细胞凋亡、抑制癌细胞转移和侵袭、诱导自噬和坏死等方面综述近几年紫草素及衍生物在抗妇科肿瘤领域的研究进展,为紫草素类化合物在妇科肿瘤中的临床研究提供参考。

Shikonin is a natural naphthoquinone compound extracted from the traditional Chinese medicine—Lithospermum, and it has anti-inflammatory, antioxidant, anti-tumor, wound healing, and other effects. In recent years, the antitumor effects of shikonin and its derivatives have been studied extensively. Numerous studies in vitro and in vivo showed that shikonin and its derivatives can effectively inhibit the initiation and development of breast cancer, cervical cancer and other gynecological malignancies, the research progress of shikonin in the field of anti-gynecological tumors in recent years was reviewed from the aspects of blocking cell cycle, promoting tumor cell apoptosis, inhibiting cancer cell metastasis and invasion, inducing autophagy and necrosis, etc. It provides a reference for the clinical research of shikonin compounds in gynecological tumors.