口服糖皮质激素对带状疱疹后遗神经痛患者的临床疗效观察

Clinical observation on curative effects of oral glucocorticoids on treatment of patients with post-herpetic neuralgia

目的观察口服糖皮质激素对带状疱疹后遗神经痛的临床疗效。方法将2018-12~2019-10该院90例带状疱疹后遗神经痛患者随机分为观察组和对照组各45例,两组患者均给予维生素B1及腺苷钴胺肌肉注射,同时给予红光照射治疗,观察组加用醋酸泼尼松片口服治疗2周。采用视觉模拟量表(Visual Analogue Scale,VAS)评分法评价疼痛程度及临床疗效。结果治疗前两组VAS评分比较差异无统计学意义(P>0.05)。观察组治疗后1周和2周VAS评分均低于对照组(P均<0.05)。观察组总有效率明显高于对照组(95.6%vs 80.0%,P<0.05)。两组未见严重不良反应。结论口服糖皮质激素对带状疱疹后遗神经痛患者疗效明确,可以有效减少疼痛程度,短期使用不良反应较少。

Objective To observe the clinical curative effects of oral glucocorticoids on treatment of patients with post-herpetic neuralgia(PHN).Methods Ninety patients with PHN who were treated in our hospital from December 2018 to October 2019 were randomly divided into observation group and control group,with 45 cases in each group.Both groups were given intramuscular injection of vitamin B1 and cobamamide,and red light irradiation therapy was given at the same time.In the observation group,oral treatment with prednisone acetate tablets was added for 2 weeks.The pain degree and clinical efficacy were evaluated by Visual Analogue Scale(VAS)score.Results There were no significant differences in VAS scores between the two groups before treatment(P>0.05).After 1 week and 2 weeks of treatment,the VAS scores of the observation group were significantly lower than those of the control group(P<0.05).The total effective rate of the observation group was significantly higher than that of the control group(95.6%vs 80.0%,P<0.05).No serious adverse reactions were found in the two groups.Conclusion Treatment with oral glucocorticoids is effective for the patients with PHN,which can effectively reduce the degree of pain and has less adverse reactions in short-term use.