中药熏洗配合手法松解对膝骨关节炎患者炎性因子的影响

Effect of traditional Chinese medicine fumigation combined with manipulation relaxation on inflammatory factors in patients with knee osteoarthritis

目的探究中药熏洗配合手法松解对膝骨关节炎患者炎性因子的影响。方法选取2017年5月至2019年4月成都骨科医院收治的96例膝骨关节炎的患者,按随机数字表法分为对照组(关节腔内注射玻璃酸钠治疗)和试验组(在对照组的基础上给予中药熏洗配合手法松解治疗),各48例,两组患者治疗周期均为5周。比较两组患者治疗5周后临床疗效;比较两组患者治疗前、治疗5周后炎性因子指标;比较两组患者治疗前及治疗1、3、5周后膝关节评分及治疗期间不良反应发生率。结果试验组患者治疗5周后临床总有效率显著高于对照组;与治疗前比,治疗5周后试验组患者血清hs-CRP水平与两组患者血清IL-6、TNF-α水平均显著降低,且试验组均显著低于对照组;与治疗前比,治疗1~5周后两组患者膝关节评分逐渐升高,且试验组显著高于对照组;试验组患者治疗期间不良反应总发生率显著低于对照组(均P<0.05)。结论中药熏洗配合手法松解治疗能够有效降低膝骨关节炎患者血清hs-CRP、IL-6、TNF-α水平,抑制炎症反应,改善膝关节功能,且具有良好的疗效与安全性。

Objective To explore the effect of traditional Chinese medicine fumigation combined with manipulation relaxation on inflammatory factors in patients with knee osteoarthritis.Methods 96 patients with knee osteoarthritis admitted to Chengdu Orthopedic Hospital from May 2017 to April 2019 were selected and randomly divided into control group(intra articular injection of sodium hyaluronate)and experimental group(given herbal fumigation combined with manual release therapy on the basis of control group)according to random number table,48 cases in each group.The treatment cycle of the two groups was 5 weeks.The clinical efficacy after 5 weeks of treatment of patients in two groups were compared;The inflammatory factor indexes before and after 5 weeks of treatment of patients in two groups were compared;The knee score before treatment and 1,3 and 5 weeks after treatment and incidence of adverse reactions during treatment were compared between the two groups.Results After 5 weeks of treatment,the clinical total effective rate of experimental group was significantly higher than that of the control group;Compared with before treatment,after 5 weeks of treatment,the serum hs-CRP levels of experimental group and the serum IL-6 and TNF-αlevels of the two groups significantly reduced,and experimental group was significantly lower than control group;Compared with before treatment,the knee joint scores of the two groups gradually increased after 1~5 weeks of treatment,and experimental group was significantly higher than control group;The total incidence of adverse reactions in experimental group was significantly lower than that in control group(all P<0.05).Conclusion Traditional Chinese medicine fumigation combined with manipulation relaxation can effectively reduce the levels of serum hs-CRP,IL-6 and TNF-αin patients with knee osteoarthritis,inhibit inflammatory reaction,improve knee joint function,and has good efficacy and safety.