椴叶鼠尾草中1个新的克罗烷型二萜化合物

A new neo-clerodane diterpenoid from Salvia tiliifolia

目的研究椴叶鼠尾草Salviatiliifolia地上部分的化学成分。方法采用硅胶、ODS、SephadexLH-20、HPLC等各种现代色谱分离技术进行系统地分离纯化,根据波谱数据对化合物进行结构鉴定。结果从椴叶鼠尾草地上部分丙酮提取物中分离得到了2个化合物,分别鉴定为1-(3-呋喃基)-8-(2-酮-2,5-二氢呋喃基)-1,7,8,9-四氢萘并[1,2-c]呋喃-3,6-二酮(1)和dugesin B(2)。结论化合物1为1个新的克罗烷型二萜化合物,命名为椴叶鼠尾酮A,活性测试结果表明化合物1无明显细胞毒活性。

Objective To study the chemical constituents of the aerial parts of Salvia tiliifolia. Methods The compounds were isolated and purified by various modern chromatographies, and their structures were identified by spectroscopic data. Results Two compounds were isolated from the acetone extract of the aerial parts of S. tiliifolia, which were elucidated as 1-(furan-3-yl)-8-(2-oxo-2,5-dihydrofuran-3-yl)-1,7,8,9-tetrahydronaphtho[1,2-c]furan-3,6-dione(1) and dugesin B(2). Conclusion Compound 1 is a new clerodane diterpene with no cytotoxicity, named as 1-keto-tilifodiolide.