Assessment of the Sensitivity and Specificity of the Established Real-time Quaking-induced Conversion(RT-QuIC)Technique in Chinese CJD Surveillance

Real-time quaking-induced conversion(RT-QuIC)assay is a newly established PrPSc-detecting method.The development of RT-QuIC improves the diagnosis of sporadic Creutzfeldt–Jakob disease(sCJD),showing good sensitivity and specificity in many countries when the method was used in cerebrospinal fluid(CSF)samples.However,in China,the sensitivity and specificity of RT-QuIC has yet to be determined due to the lack of definitive diagnosis samples.