局灶节段性肾小球硬化致病基因研究进展

Progress in pathogenic genes of focal segmental glomerulosclerosis

局灶节段性肾小球硬化(FSGS)以局灶节段分布的肾小球硬化及足细胞的足突融合为特征,是儿童终末期肾脏病的主要原因。其发病机制尚未完全阐明,但近年来随着分子遗传学的发展,已在FSGS患者中定位超过30个致病基因,为足细胞结构和功能的破坏在其发病机制中提供了证据。现将FSGS的常见致病基因研究进展进行综述。

Focal segmental glomerulosclerosis(FSGS)is characterized by the fusion of foot processes of podocytes,and can lead to end-stage kidney disease in children.The pathogenesis of FSGS has not been fully clarified,but more than 30 pathogenic genes have been identified in FSGS patients in recent years with the development of molecular genetics.These findings prove that the destruction of the structure and function of podocytes plays a role in the pathogenesis of FSGS.In this paper,the research progress of common pathogenic genes of FSGS was reviewed.