血小板参与动脉粥样硬化斑块形成的分子途径

The Molecular Mechanism of Platelets in Atherosclerotic Plaque Formation

血小板在血栓形成,血液凝固,维持血管稳态及修复血管损伤等生理病理过程中起重要作用。近年来研究发现血小板也可作为炎症细胞参与机体宿主防御,发挥免疫功能。动脉粥样硬化是一种慢性血管炎症性疾病,在血管炎症发生过程中,血小板可通过表面受体或释放储存在血小板颗粒中的分子促进血小板与炎症细胞(如血管内皮细胞、平滑肌细胞、单核细胞)相互作用,从而参与动脉粥样硬化发生。本文主要围绕血小板参与动脉粥样硬化斑块形成的途径,及其作为动脉粥样硬化早期防治靶点的最新进展进行综述。

Platelets play an important role in the physiological and pathological processes including thrombosis,coagulation,vascular homeostasis,and repairing.In recent years,accumulated evidence revealed that platelets could act as inflammatory cells participating in the host defense and inducing immune response.Atherosclerosis is a chronic vascular inflammatory disease.During vascular inflammation,platelets interact with inflammatory cells(such as vascular endothelial cells,smooth muscle cells,monocytes)through surface receptors or cytokines stored in platelet dense orαgranules participating in the atherogenesis.This review focuses on the molecular pathways of platelets in the formation of atherosclerotic plaque and their latest progress in targeted therapy for atherosclerosis treatment.