分析西洛他唑片对老年脑血管疾病神经介入术后抗血栓作用的临床效果

Analysis of the clinical effect of cilostazol tablets on the antithrombotic effect of senile cerebrovascular diseases after neurointervention

目的分析西洛他唑片对老年脑血管疾病神经介入术后抗血栓作用的临床效果。方法 70例行神经介入术治疗的老年脑血管疾病患者为试验样本,以随机数字表法分为对照组及观察组,各35例。对照组采取阿司匹林+氯吡格雷治疗,观察组在对照组的基础上加用西洛他唑片治疗。比较两组患者的治疗效果、6个月后脑血管再狭窄率,治疗前后的血小板聚集率及血小板平均体积。结果观察组患者的治疗总有效率91.4%高于对照组57.1%, 6个月后脑血管再狭窄率2.9%低于对照组的20.0%,差异均具有统计学意义(P<0.05)。治疗前,两组患者的血小板聚集率比较,差异无统计学意义(P>0.05);观察组患者治疗后1、4、8周的血小板聚集率分别为(53.34±8.23)%、(44.12±8.14)%、(40.12±8.14)%,均明显低于对照组的(68.02±9.02)%、(62.57±8.59)%、(55.95±9.23)%,差异均具有统计学意义(P<0.05)。两组患者治疗前、治疗后1周、治疗后4周、治疗后8周的血小板平均体积比较,差异均无统计学意义(P>0.05)。结论对行神经介入术治疗的老年脑血管疾病患者应用西洛他唑片治疗可取得很好的疗效,能有效抑制血栓的形成,治疗安全性有保障。

Objective To analyze the clinical effect of cilostazol tablets on the antithrombotic effect of senile cerebrovascular diseases after neurointervention. Methods A total of 70 cases of senile cerebrovascular diseases after neurointervention were divided into control group and observation group by random numerical table, with 35 cases in each group. The control group was treated with aspirin and clopidogrel, and the observation group was treated with cilostazol tablets on the basis of the control group. The therapeutic effect, restenosis rate 6 months later, platelet aggregation rate and average platelet volume before and after treatment were compared between the two groups. Results The total effective rate of treatment 91.4% of the observation group was higher than that of the control group 57.1%, and restenosis rate 6 months later 2.9% was lower than that of the control group 20.0%, and the difference was statistically significant(P<0.05). Before treatment, there was no statistically significant difference in platelet aggregation rate between the two groups(P>0.05). 1, 4 and 8 weeks after treatment, platelet aggregation rate of the observation group was(53.34±8.23)%,(44.12±8.14)% and(40.12±8.14)% respectively, which was obviously lower than that of the control group(68.02±9.02)%,(62.57±8.59)% and(55.95±9.23)%, and the difference was statistically significant(P<0.05). Before treatment, 1, 4 and 8 weeks after treatment, there was no statistically significant difference in average platelet volume between the two groups(P>0.05). Conclusion Cilostazol tablets can achieve good curative effect on senile patients with cerebrovascular disease undergoing neurointervention, which can effectively inhibit the formation of thrombosis and ensure the safety of treatment.