四联疗法和常规三联疗法在胃溃疡中的效果及对患者临床症状和血清学的影响

The effects of quadruple therapy and conventional triple therapy in gastric ulcer and their influence on patients’clinical symptoms and serology

目的分析四联疗法和常规三联疗法在胃溃疡中的效果,以及对患者临床症状和血清学的影响。方法 78例胃溃疡患者,根据治疗方式的不同分为观察组和对照组,各39例。对照组采用常规三联疗法,观察组采用四联疗法。对比两组患者治疗效果、幽门螺杆菌根除率、临床症状改善情况、血清炎症因子水平以及不良反应发生情况。结果观察组治疗总有效率94.87%、幽门螺杆菌根除率92.31%均高于对照组的79.49%、74.36%,差异均具有统计学意义(P<0.05)。治疗后,对照组腹痛、腹胀、反酸嗳气症状积分分别为(1.10±0.32)、(1.12±0.37)、(1.32±0.52)分,均高于观察组的(0.25±0.11)、(0.28±0.10)、(0.37±0.14)分,差异具有统计学意义(P<0.05)。对照组IL-6水平(21.33±4.82)ng/L高于观察组的(13.25±2.74)ng/L, IL-10水平(15.14±2.20)ng/L低于观察组的(22.08±3.47)ng/L,差异均具有统计学意义(P<0.05)。观察组不良反应发生率7.69%与对照组的12.82%比较,差异无统计学意义(P>0.05)。结论常规三联疗法和四联疗法均能有效治疗胃溃疡,但四联疗法能更有效地改善临床症状,减轻炎症反应和提高幽门螺杆菌根除率,值得应用。

Objective To analyze the effect of quadruple therapy and conventional triple therapy in gastric ulcer and their influence on patients’clinical symptoms and serology.Methods A total of 78 patients with gastric ulcer were divided into observation group and control group,with 39 cases in each group.The control group received conventional triple therapy,and the observation group received quadruple therapy.The therapeutic effect,Helicobacter pylori eradication rate,clinical symptoms improvement,serum inflammatory factor levels and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment 94.87%and Helicobacter pylori eradication rate 92.31%of the observation group were higher than 79.49%and 74.36%of the control group,and the difference was statistically significant(P<0.05).After treatment,symptom score of abdominal pain,abdominal distension,acid regurgitation and belching of the observation group were(1.10±0.32),(1.12±0.37)and(1.32±0.52)points,which were higher than(0.25±0.11),(0.28±0.10)and(0.37±0.14)points of the observation group,and the difference was statistically significant(P<0.05).IL-6(21.33±4.82)ng/L of the control group was higher than(13.25±2.74)ng/L of the observation group,and IL-10(15.14±2.20)ng/L was lower than(22.08±3.47)ng/L of the observation group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions 7.69%of the observation group had no statistically significant difference compared with 12.82%of the control group(P>0.05).Conclusion Conventional triple therapy and quadruple therapy can effectively treat gastric ulcers,but quadruple therapy can more effectively improve clinical symptoms,reduce inflammation and increase the eradication rate of Helicobacter pylori,and is worthy of application.