宫颈癌根治性放化疗预后的影响因素分析

An analysis of the prognosis factors for long-term survival in patients with cervical cancer

目的:分析宫颈癌根治性放化疗预后的影响因素,为宫颈癌的治疗提供最佳放化疗结合模式。方法:回顾性分析2009年7月至2014年1月收治的213例接受根治性放化疗的宫颈癌患者的临床资料。放疗采用三维适形放射治疗技术,化疗方案以铂类药物为基础。Kaplan-Meier法计算OS,采用Logrank法检验并进行单因素分析,Cox风险回归模型进行多因素预后分析。结果:随访率96.7%,全组1、3、5年OS为96.7%、79.3%和65.2%。单因素分析显示影响OS因素为年龄、分期。多因素分析分期和化疗周期数是影响OS的独立预后因素。结论:同步放化疗模式是治疗宫颈癌的主要方法,化疗周期数3~4次,可能是最佳的化疗次数,可以预防远处转移和改善总生存。

Objective:To analyse the efficacy chemoradiotherapy in the treatment of cervical cancer and its influencing factors,to supply an best optional combination mode of chemoradiotherapy.Methods:A retrospective study was performed.213 patients with cervical cancer from July 2009 to January 2014 were enroll to this study.All patients received the chemoradiotherapy.The overall survival(OS) was calculated by Kaplan-Meier methods and analyzed using the Logrank test.Cox model was used for multivariate prognostic analysis.Resluts:The rate of follow-up was 96.7%.The 1-,3-,5-year OS were 96.7%,79.3% and 65.2%.The univariate analysis revealed that age and FIGO stage were influencing factors to OS. The multivariate analysis revealed that stage and more than 3 cycles of chemotherapy were independent prognostic factors for OS. Conclusion: The model of chemoradiotherapy could be the best treatment to the patients with cervical cancer.3 or 4 cycles of chemotherapy may improve the rate of OS and less the rate of metastasis.