医用敷料用柔性金属电极的制备及其细胞毒性分析

Preparation and cytotoxicity analysis of flexible metal electrodes for medical dressings

为研究用于医用敷料的柔性金属电极的制备可行性和安全性,以涤纶非织造布为基布,通过丝网印刷技术,制备以锌为负电极、银为正电极的柔性微电流生物医用敷料。探讨了电极制备过程中的分散剂种类、分散剂含量及黏合剂含量对金属电极电学性能的影响,并分析了金属电极可能引起的细胞毒性问题。实验结果表明:丝网印刷技术能在基布表面均匀地负载锌、银微纳米颗粒;1%的羧甲基纤维素钠和0.5%的吐温-80分别作为锌、银颗粒的分散剂,能使金属颗粒具有良好的分散性;5%和15%的水性丙烯酸乳液分别作为锌、银金属电极的黏合剂,可使电极具有优良的电性能;当金属质量分数为0.5%~1.0%时,金属电极表现出良好的细胞相容性,可作为生物医用敷料为伤口提供外源性微电流。

In order to study the feasibility and safety of the preparation of flexible metal electrodes for medical dressings,a flexible micro-current biomedical dressing was prepared,taking a polyester nonwoven fabric as the base fabric,by the screen printing technique,where zinc was used for the negative electrode and silver the positive.The effects of dispersant type,dispersant content and binder content on the electrical properties of the metal electrodes were discussed,and the possible cytotoxicity problems caused by the metal electrodes were studied.The results show that the screen printing technique made the silver and zinc micro-nano particles adhere to the fabric surface uniformly.1%carboxy methyl cellulose sodium(CMC)and 0.5%Tween-80 are found to be the optimal condition for good dispersion of the zinc and silver particles.Waterborne acrylic emulsion with mass fraction of 5%and 15%enabled zinc and silver metal electrodes to have excellent electrical properties respectively.The metal electrodes show good cytocompatibility with 0.5%-1.0%metal content,which is suitable for biomedical dressings to provide exogenous micro-current for the wound.