碳酸镧治疗尿毒症维持性血液透析患者高磷血症的疗效

Effect of Lanthanum Carbonate on Hyperphosphatemia in Maintenance Dialysis Patients with Uremia

目的探讨碳酸镧治疗尿毒症维持性血液透析患者高磷血症的疗效。方法选取94例并发高磷血症的尿毒症维持性血液透析患者,按治疗方式不同分为对照组47例和研究组47例,对照组给予碳酸钙D3片治疗,研究组给予碳酸镧片治疗。比较2组治疗后甲状旁腺激素(PTH)、血磷和血钙水平、临床疗效及不良反应(呕吐与恶心、腹泻与腹痛)发生情况。结果研究组治疗后PTH、血磷和血钙水平均低于对照组(均P<0.05);研究组临床疗效优于对照组(P<0.05);研究组不良反应发生率低于对照组(P<0.05)。结论用碳酸镧片治疗并发高磷血症的尿毒症维持性血液透析患者,能够有效降低患者血磷、血钙和PTH水平,从而减少高钙血症、心血管不良事件的风险,临床有效率较高,有效改善患者预后。

Objective To investigate the effect of lanthanum carbonate on hyperphosphatemia in maintenance dialysis patients with uremia.Methods Ninety-four maintenance dialysis patients with uremia complicated by hyperphosphatemia were assigned to receive either calcium carbonate D3 tablets(control group,n=47)or lanthanum carbonate tablets(study group,n=47).The blood levels of parathyroid hormone(PTH),phosphorus and calcium,clinical efficacy and adverse reactions(vomiting,nausea,diarrhea and abdominal pain)were compared between the two groups after treatment.Results Compared with control group,blood levels of PTH,phosphorus and calcium and incidence of adverse reactions were decreased and clinical efficacy was improved in study group(P<0.05).Conclusion Lanthanum carbonate tablets can effectively decrease blood levels of phosphorus,calcium and PTH,and thus reduce the risks of hypercalcemia and cardiovascular adverse events in maintenance dialysis patients with uremia.In addition,treatment with lanthanum carbonate can increase clinical efficacy and improve prognosis.