补肾健脾方联合地屈孕酮治疗先兆流产疗效观察

Curative effect of Bushen Jianpi Decoction combined with didroxyprogesterone in the treatment of threatened abortion

目的观察补肾健脾方联合地屈孕酮治疗先兆流产的临床效果。方法选择上海市金山区中西医结合医院妇科2018年1月至2019年12月收治的80例先兆流产患者,根据随机数表法分为观察组和对照组各40例,对照组给予地屈孕酮治疗,观察组在对照组基础上加用补肾健脾方治疗,两周后比较两组患者的治疗效果、临床症状缓解时间和围生儿结局。结果观察组患者的临床治疗总有效率为95.0%,明显高于对照组的80.0%,差异有统计学意义(P<0.05);治疗后,观察组患者的阴道流血、腹痛、腰酸等临床症状改善时间分别为(5.01±0.91)d、(4.87±1.63)d、(4.21±1.02)d,明显短于对照组的(7.09±1.22)d、(5.98±0.98)d、(5.89±1.65)d,差异均有显著统计学意义(P<0.01);观察组患者的低体重儿出生率为0,明显低于对照组的15.6%,差异有统计学意义(P<0.05)。结论补肾健脾方联合地屈孕酮应用于先兆流产的治疗,可快速缓解患者的临床症状,提高临床疗效,降低低体质量儿发生风险。

Objective To discuss the effect of Bushen Jianpi Decoction combined with didroprogesterone in the treatment of threatened abortion.Methods Eighty patients with threatened abortion from Department of Obstetrics and Gynecology,Shanghai Jinshan District Hospital of Integrated Traditional Chinese and Western Medicine during January 2018 and December 2019 were randomly divided into observation group and control group,with 40 patients in each group.The control group was treated with didroxyprogesterone,and the observation group was treated with Bushen Jianpi Decoction combined with didroxyprogesterone,for two weeks.Two weeks later,the clinical treatment effect,clinical symptom relief time,and perinatal outcome were compared between the two groups.Results The clinical effective rate of the observation group was 95.0%,significantly higher than 80.0%of the control group(P<0.05).After treatment,the improvement time of vaginal bleeding,abdominal pain,and lumbar acid in the observation group were(5.01±0.91)d,(4.87±1.63)d,(4.21±1.02)d,significantly shorter than(7.09±1.22)d,(5.98±0.98)d,(5.89±1.65)d in the control group(P<0.01).The birth rate of low body weight infants in the observation group was 0,significantly lower than 15.6%in the control group(P<0.05).Conclusion Bushen Jianpi Decoction combined with didroxyprogesterone can treat threatened abortion effectively,which can quickly relieve the clinical symptoms,improve the clinical efficacy,and reduce the risk of low birth weight infants.