腹腔镜术后应用GnRH-α对EM患者ER、PR表达及免疫功能的影响

Effect of using GnRH-α after laparoscopic surgery on ER,PR expression and immune function of endometriosis patients

目的腹腔镜术后应用促性腺激素释放激素激动剂(GnRH-α)对子宫内膜异位症(EM)患者雌激素受体(ER)、孕激素受体(PR)表达及免疫功能的影响。方法选取我院收治的行腹腔镜手术治疗的EM患者86例,使用简单随机法将其分为观察组和对照组,每组43例。对照组术后使用孕三烯酮治疗,观察组术后采用GnRH-α治疗。比较两组ER、PR表达,免疫功能、不良反应发生情况及术后疼痛缓解情况。结果观察组ER、PR表达低于对照组(P<0.05),IgA、IgG水平高于对照组(P<0.05)。两组不良反应发生率无差别(P>0.05);观察组疼痛缓解程度优于对照组(P<0.05)。结论腹腔镜术后应用GnRH-α能够有效调节EM患者ER、PR表达和免疫功能水平,缓解疼痛,安全可靠。

Objective To investigate the effect of using gonotropin-releasing hormone agonist(GnRH-α)after laparoscopic surgery on the expression of estrogen receptor(ER)and progesterone receptor(PR)and immune function of patients with endometriosis(EM).Methods A total of 86 patients with EM who received laparoscopic surgery in our hospital were selected and randomly divided into the observation group and the control group,43 cases in each group.The control group was treated with gestational trienone after surgery,while the observation group was treated with GnRH-α.The expression of ER and PR,the immune function,adverse reactions and postoperative pain relief were compared between the two groups.Results The expression of ER and PR in the observation group were lower than those in the control group(P<0.05),and the levels of IgA and IgG were higher than those in the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05);the pain relief of the ob⁃servation group was better than that of the control group(P<0.05).Conclusion The application of GNRh-αafter lapa⁃roscopic surgery can effectively regulate the expression of ER,PR and immune function,relieve pain,which is safe and reliable.