化脓灸合胸腺五肽注射液治疗稳定期慢性阻塞性肺疾病40例临床观察

Clinical effect of blistering moxibustion combined with thymopentin injection in treatment of stable stage of chronic obstructive pulmonary disease: An analysis of 40 cases

目的:观察化脓灸联合胸腺五肽注射液治疗稳定期慢性阻塞性肺疾病(COPD)的临床疗效。方法:将稳定期COPD患者80例随机分为治疗组和对照组,每组各40例。2组均给予基础治疗,对照组加用胸腺五肽注射液治疗,治疗组在对照组治疗的基础上联合化脓灸治疗,治疗3个月后比较2组中医证候疗效,肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC],血气分析指标[动脉血氧分压(Pa O2)、二氧化碳分压(Pa CO2)]变化,以及疗程结束后随访1年的急性加重人均次数。结果:中医证候疗效总有效率治疗组为92.50%(37/40),对照组为62.50%(25/40),组间比较,差异有统计学意义(P <0.01);2组FEV1、FVC、FEV1/FVC、Pa O2、Pa CO2治疗前后组内组间比较及治疗后组间比较,差异均有统计学意义(P <0.01或P <0.05);随访1年急性发作人均次数2组组间比较,差异有统计学意义(P <0.05)。结论:化脓灸联合胸腺五肽注射液治疗COPD,能缓解中医症状,改善肺功能及血气分析指标,减少急性发作次数,值得临床推广应用。

Objective: To investigate the clinical effect of blistering moxibustion combined with thymopentin injection in the treatment of stable stage of chronic obstructive pulmonary disease( COPD). Methods: A total of 80 patients with stable stage of COPD were randomly divided into treatment group and control group,with 40 patients in each group.The patients in the control group were given basic treatment and thymopentin injection,and those in the treatment group were given blistering moxibustion in addition to the treatment in the control group. After 3 months of treatment,the two groups were compared in terms of treatment outcome of traditional Chinese medicine( TCM) syndrome,pulmonary function [forced expiratory volume in the first second( FEV1),forced vital capacity( FVC),and FEV1/FVC ratio],blood gas parameters [arterial partial pressure of oxygen( Pa O2) and arterial partial pressure of carbon dioxide( Pa CO2) ],and mean number of acute exacerbations per person during the 1-year follow-up after treatment ended. Results: There was a significant difference in the overall response rate of TCM syndrome between the treatment group and the control group[92. 50%( 37/40) vs 62. 50%( 25/40),P < 0. 01]. Both groups had significant changes in FEV1,FVC,FEV1/FVC,Pa O2,and Pa CO2 after treatment,and there were significant differences in these indices between the two groups after treatment( P < 0. 01 or P < 0. 05). There was a significant difference in the mean number of acute exacerbations per person during the 1-year follow-up between the two groups( P < 0. 05). Conclusion: In the treatment of COPD,blistering moxibustion combined with thymopentin injection can effectively alleviate TCM symptoms,improve pulmonary function and blood gas parameters,and reduce acute exacerbations,and therefore,it holds promise for clinical application.