银翘散联合三仁汤加减治疗新型冠状病毒肺炎普通型湿毒郁肺证20例

Clinical Effect of Yinqiao Powder Combined with Modified Sanren Decoction in Treatment of Common-type Coronavirus Disease 2019 with Dampness-Toxicity Stagnation in Lung:An Analysis of 20 Cases

目的回顾性观察银翘散联合三仁汤加减治疗新型冠状病毒肺炎普通型湿毒郁肺证患者的临床疗效。方法采用回顾性临床研究方法,收集36例新型冠状病毒肺炎普通型湿毒郁肺证患者的临床资料,将其分为治疗组和对照组。治疗组20例采用常规治疗联合银翘散和三仁汤加减,对照组16例采用常规治疗。以中医证候积分、中医证候疗效、体温复常时间、病毒核酸转阴率、肺部病灶吸收情况作为结局指标评价治疗效果。结果两组患者治疗后中医证候评分均较治疗前显著下降(P<0.05),治疗组中医证候积分下降程度明显大于对照组(P<0.05)。治疗组中医证候疗效明显优于对照组(P<0.05)。与对照组比较,治疗组患者体温复常时间明显缩短(P<0.05),治疗10 d后病毒核酸转阴率明显升高(P<0.05)。两组患者肺部病灶吸收情况比较,差异无统计学意义(P>0.05)。结论在西医常规治疗基础上,采用银翘散联合三仁汤加减治疗能够改善新型冠状病毒肺炎普通型湿毒郁肺证患者临床症状,缩短体温复常时间,提高病毒核酸转阴率。

Objective To investigate the clinical effect of Yinqiao Powder combined with Modified Sanren Decoction in the treatment of common-type coronavirus disease 2019(COVID-19)with dampness-toxicity stagnation in lung through retrospective observation.Methods A retrospective analysis was performed for the clinical data of 36 patients with common-type COVID-19 with dampness-toxicity stagnation in lung,and the patients were divided into treatment group and control group.The 20 patients in the treatment group were given conventional treatment combined with Yinqiao Powder and Modified Sanren Decoction,and the 16 patients in the control group were given conventional treatment.Treatment outcome was evaluated based on the following outcome measures:traditional Chinese medicine(TCM)syndrome score,outcome of TCM syndrome,time to recovery of body temperature,clearance rate of viral nucleic acid,and pulmonary lesion absorption.Results Both groups had a significant reduction in TCM syndrome score after treatment(P<0.05),and the treatment group had a significantly greater reduction than the control group(P<0.05).The treatment group had a significantly better outcome of TCM syndrome than the control group(P<0.05).Compared with the control group,the treatment group had a significantly shorter time to recovery of body temperature(P<0.05)and a significant increase in clearance rate of viral nucleic acid after 10 days of treatment(P<0.05).There was no significant difference in lung lesion absorption between the two groups(P>0.05).Conclusion In addition to conventional treatment,Yinqiao Powder combined with Modified Sanren Decoction can improve clinical symptoms,shorten the time to recovery of body temperature,and improve clearance rate of viral nucleic acid in patients with COVID-19 with dampness-toxicity stagnation in lung.