斑蝥素中毒机体各系统损伤及其机制的研究进展

Research Progress on Multiple Organ Damage and Mechanism of Cantharidin Poisoning

斑蝥素中毒已被证实可引起多器官损害,由此造成的急性循环衰竭、急性肾衰竭或多器官功能衰竭是斑蝥素中毒患者的常见死因。目前有关斑蝥素中毒主要靶器官损伤及其机制的研究尚未明确。本文通过梳理近年来国内外有关斑蝥素中毒的毒理病理学研究文献,系统综述了斑蝥素中毒后机体消化系统、循环系统、呼吸系统、泌尿系统、生殖系统、皮肤黏膜、免疫系统和神经系统的毒理病理损伤及机制的最新研究进展,为进一步完善斑蝥素中毒分子毒理学机制及临床干预斑蝥素中毒的决策制定提供借鉴。

Cantharidin poisoning has been proven to cause multiple organ damage.Acute circulatory failure,acute renal failure,and multiple organ failure resulting from cantharidin poisoning are the main causes of death for patients with cantharidin poisoning.However,research on the damage of main target organs and mechanism of cantharidin poisoning is not clear.This paper reviews the latest toxicological and pathological research literatures at home and abroad related to cantharidin poisoning and comprehensively summarizes the latest research progress on the toxicological and pathological damage and mechanism of the digestive system,circulatory system,respiratory system,urinary system,reproductive system,skin mucosa,immune system,and nervous system after cantharidin poisoning,to provide reference for improving the molecular toxicological mechanism of cantharidin poisoning and decisionmaking in the clinical intervention of cantharidin poisoning.