CT扫描评估原发性肝癌介入联合分子靶向治疗效果的价值分析

Value of CT scan in Evaluating the Effect of Intervention Combined with Molecular Targeted Therapy on Primary Hepatic Carcinoma

目的探讨并分析电子计算机断层扫描(Computed Tomography,CT)对原发性肝癌(hepatic carcinoma,HCC)介入联合分子靶向治疗效果的评估价值。方法选取2016年4月至2018年8月期间在我院行肝动脉插管化疗栓塞(transcatheter arterial chemoembolization,TACE)联合阿帕替尼治疗的HCC患者37例临床资料进行回顾性分析,患者均于术前及术后进行CT检查,观察肿瘤内碘油沉积情况及血供情况。结果37例患者经联合治疗6个月后,治疗总有效率为94.59%。相关性分析显示,联合治疗4周后,肿瘤内碘油分布与治疗6个月后疗效呈正相关(r=0.657,P<0.05),联合治疗4周后,肿瘤血供有无与治疗6个月后治疗疗效呈负相关(r=-0.561,P<0.05)。结论采用CT扫描评估HCC患者TACE联合阿帕替尼治疗疗效具有一定应用价值。

Objective To evaluate the value of computed tomography(CT)scan in evaluating the effect of intervention combined with molecular targeted therapy on primary hepatic carcinoma(HCC).Methods A retrospective analysis was performed on the clinical data of 37 patients with HCC who underwent transcatheter arterial chemoembolization(TACE)combined with Apatinibin the hospital from April 2016 to August 2018.CT examination was performed on the patients before and after surgery.The deposition of iodized oil and blood supply in the tumor were observed.Results After 6 months of combined treatment for 37 patients,the total effective rate of treatment was 94.59%.Correlation analysis showed that after 4 weeks of combined treatment,the distribution of iodized oil in the tumor was positively correlated with the efficacy after 6 months of treatment(r=0.657,P<0.05).After 4 weeks of combined treatment,the presence or absence of the blood supply in the tumor was negatively correlated with the efficacy after 6 months of treatment(r=-0.561,P<0.05).Conclusion CT scan is valuable in evaluating the therapeutic effect of TACE combined with Apatinib in patients with HCC.