腹前同源盒1基因多态性与非综合征性唇腭裂易感性的Meta分析

A Meta-analysis of the credibility between ventral anterior homeobox 1(VAX1)polymorphisms and non-syndromic cleft lip/palate(NSCL/P)susceptibility

[目的]系统评价腹前同源盒1(VAX1)基因多态性与非综合征性唇腭裂易感性的关联。[方法]检索PubMed、EMbase、Web of Science和中国知网数据库,检索时限均为建库到2020年3月31日,共检索到126篇文献。应用RevMan 5.3与STATA 15.0对所有提取到的数据进行分析。[结果]在进行文献筛选后,共纳入13篇相关文献,其中试验组3963例,对照组2557例。分析结果显示:VAX1基因rs7078160位点[A vs G:OR=1.33,95%CI(1.17,1.51),P<0.001;AG vs GG:OR=1.29,95%CI(1.15,1.46),P<0.001;AA vs GG:OR=1.67,95%CI(1.23,2.28),P=0.001;AA vs AG+GG:OR=1.52,95%CI(1.16,2.01),P=0.003;AA+AG vs GG:OR=1.37,95%CI(1.22,1.53),P<0.001]与rs4752028位点[C vs T:OR=1.60,95%CI(1.20,2.14),P=0.001;CC vs TT:OR=2.65,95%CI(1.46,4.81),P=0.001;CC vs CT+TT:OR=2.34,95%CI(1.32,4.14),P=0.004;CC+CT vs TT:OR=1.62,95%CI(1.10,2.38),P=0.014]是非综合征性唇腭裂的易感因素。[结论]VAX1基因rs7078160位点多态性与非综合征性唇腭裂有关,A位点是危险因素;VAX1基因rs4752028位点多态性与非综合征性唇腭裂可能有关,C位点是危险因素。

Objective:To evaluate the credibility between VAX1 polymorphisms and non-syndromic cleft lip/palate(NSCL/P)susceptibility.Methods:PubMed,EMbase,Web of Science and CNKI databases were retrieved.The retrieval time was from the inception to March 31,2020.A total of 126 articles were retrieved.Revman 5.3 and Stata 15.0 were used for analysis of extracted data.Results:After literature screening,a total of 13 related literatures were included,involving 3963 patients and 2557 controls in this study.The results showed that rs7078160[A vs G:OR=1.33,95%CI(1.17,1.51),P<0.001;AG vs GG:OR=1.29,95%CI(1.15,1.46),P<0.001;AA vs GG:OR=1.67,95%CI(1.23,2.28),P=0.001;AA vs AG+GG:OR=1.52,95%CI(1.16,2.01),P=0.003;AA+AG vs GG:OR=1.37,95%CI(1.22,1.53),P<0.001]and rs4752028[C vs T:OR=1.60,95%CI(1.20,2.14),P=0.001;CC vs TT:OR=2.65,95%CI(1.46,4.81),P=0.001;CC vs CT+TT:OR=2.34,95%CI(1.32,4.14),P=0.004;CC+CT vs TT:OR=1.62,95%CI(1.10,2.38),P=0.014]were the suspectable factors of non-syndromic cleft lip/palate(NSCL/P).Conclusion:Rs7078160 polymorphism of VAX1 gene is associated with non-syndromic cleft lip/palate(NSCL/P),and allele A is a risk factor.Rs4752028 polymorphism of VAX1 gene may be associated with non-syndromic cleft lip/palate(NSCL/P),and allele C locus is a risk factor.