度洛西汀与舍曲林治疗老年抑郁症伴疼痛患者的临床效果与安全性比较

Comparison of clinical efficacy and safety of duloxetine and sertraline in the treatment of elderly patients with depression and pain

目的比较度洛西汀与舍曲林治疗老年抑郁症伴疼痛患者的临床效果与安全性。方法应用随机数字表法将40例老年抑郁症伴疼痛患者分为度洛西汀组(度洛西汀治疗)和舍曲林组(舍曲林治疗),各20例。比较两组的HAMD、HAMA、VAS评分及不良反应发生情况。结果治疗2、4周后,两组的HAMD及HAMA评分均较治疗前降低,差异具有统计学意义(P<0.05)。治疗2、4周后,两组的VAS评分均较治疗前降低,差异具有统计学意义(P<0.05);治疗2周后,度洛西汀组的VAS评分低于舍曲林组,差异具有统计学意义(P<0.05)。两组的不良反应总发生率无显著差异(P>0.05)。结论度洛西汀与舍曲林在老年抑郁症伴疼痛患者的治疗中均具有较好效果,不良反应少,但度洛西汀起效快,可快速缓解患者的躯体疼痛症状。

Objective To compare the clinical efficacy and safety of duloxetine and sertraline in the treatment of elderly patients with depression and pain.Methods A total of 40 elderly patients with depression and pain were divided into duloxetine group(duloxetine treatment)and sertraline group(sertraline treatment)by random number table method,with 20 cases in each group.The HAMD,HAMA,VAS scores and adverse reactions were compared between the two groups.Results After 2 and 4 weeks of treatment,the HAMD and HAMA scores of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After 2 and 4 weeks of treatment,the VAS scores of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05);after 2 weeks of treatment,the VAS score of the duloxetine group was lower than that of the sertraline group,and the difference was statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Both duloxetine and sertraline in the treatment of elderly patients with depression and pain have good effects with few adverse reactions,but duloxetine has a quick onset and can quickly relieve the physical pain symptoms of patients.