丹参川芎嗪注射液联合阿托伐他汀对急性脑梗死患者Hcy、hs-CRP及血小板聚集率的影响

Effect of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin on Hcy,hs-CRP and platelet aggregation rate in patients with acute cerebral infarction

目的观察丹参川芎嗪注射液联合阿托伐他汀对急性脑梗死(ACI)患者同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)及血小板聚集率的影响。方法将本院2018年2月至2019年8月收治的104例ACI患者按照随机数字表法分为参照组(n=52)和治疗组(n=52)。参照组采用阿托伐他汀治疗,治疗组采用丹参川芎嗪注射液联合阿托伐他汀治疗。比较两组的Hcy、hs-CRP水平、血小板聚集率、临床疗效及不良反应发生情况。结果治疗后,两组的Hcy、hs-CRP水平及血小板聚集率均显著下降,且治疗组低于参照组(P<0.05)。治疗组的治疗总有效率显著高于参照组(P<0.05)。两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论丹参川芎嗪注射液联合阿托伐他汀治疗ACI,可显著下调Hcy、hs-CRP水平及血小板聚集率,提高临床疗效,且安全性高。

Objective To observe the effect of salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin on homocysteine(Hcy),high sensitivity C-reactive protein(hs-CRP)and platelet aggregation rate in patients with acute cerebral infarction(ACI).Methods A total of 104 patients with ACI treated in our hospital from February 2018 to August 2019 were divided into reference group(n=52)and treatment group(n=52)according to random number table method.The reference group was treated with atorvastatin,and the treatment group was treated with salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin.Hcy,hs-CRP levels,platelet aggregation rate,clinical efficacy and adverse reactions were compared between the two groups.Results After treatment,the levels of Hcy,hs-CRP and platelet aggregation rate in the two groups significantly decreased,and those in the treatment group were lower than the reference group(P<0.05).The total effective rate of treatment in the treatment group was significantly higher than that in the reference group(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Salviae miltiorrhizae and ligustrazine hydrochloride injection combined with atorvastatin in the treatment of ACI can significantly down-regulate Hcy,hs-CRP levels and platelet aggregation rate,improve clinical efficacy,and has high safety.