胺碘酮联合美托洛尔治疗快速心律失常的效果和安全性

Efficacy and safety of amiodarone combined with metoprolol in the treatment of tachyarrhythmia

目的探讨胺碘酮联合美托洛尔治疗快速心律失常的效果和安全性。方法将2017年6月至2019年6月急诊科胸痛中心收治的100例快速心律失常患者随机分为观察组(n=50,胺碘酮联合美托洛尔治疗)和对照组(n=50,单用胺碘酮治疗)。比较两组的治疗效果。结果观察组治疗总有效率高于对照组(P<0.05)。治疗后,两组的E/A、LVEF均升高,且观察组高于对照组(P<0.05)。治疗后,观察组的心率、收缩压、舒张压均低于对照组(P<0.05)。观察组卧床时间、住院时间短于对照组(P<0.05)。结论胺碘酮联合美托洛尔治疗快速心律失常可增强临床效果,明显改善心功能,稳定心率和心压,且具有较高安全性。

Objective To investigate the efficacy and safety of amiodarone combined with metoprolol in the treatment of tachyarrhythmia.Methods A total of 100 patients with tachyarrhythmia admitted in the chest pain center of emergency department from June 2017 to June 2019 were randomly divided into observation group(n=50,treated with amiodarone combined with metoprolol)and control group(n=50,treated with amiodarone alone).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment of the observation group was higher than that of the control group(P<0.05).After treatment,the E/A and LVEF of the two groups increased,and those in the observation group were higher than the control group(P<0.05).After treatment,the heart rate,systolic pressure and diastolic pressure of the observation group were lower than those of the control group(P<0.05).The bed rest time and hospitalization time of the observation group were shorter than those of the control group(P<0.05).Conclusion Amiodarone combined with metoprolol in the treatment of tachyarrhythmia can enhance clinical effect,significantly improve cardiac function,stabilize heart rate and heart pressure,and has high safety.