不同剂量右美托咪定对腹腔镜手术患者的麻醉效果及安全性

Anesthetic effect and safety of different doses of dexmedetomidine in patients undergoing laparoscopic surgery

目的分析不同剂量右美托咪定对腹腔镜手术患者的麻醉效果及安全性。方法将在我院接受腹腔镜手术治疗的100例患者随机分为对照组和观察组,各50例。两组均静脉输注右美托咪定,对照组剂量为0.8μg/kg,观察组剂量为0.4μg/kg。比较两组的麻醉效果。结果观察组的定向力恢复时间、PACU停留时长及苏醒时间均短于对照组,Riker镇静-躁动评分明显低于对照组(P<0.05)。麻醉后12 h,两组CD3+、CD4+及CD4+/CD8+均较麻醉前降低,但观察组高于对照组(P<0.05)。手术开始后30 min及手术结束时,观察组的TcPO2高于对照组(P<0.05)。观察组的不良反应总发生率及POCD发生率低于对照组(P<0.05)。结论在腹腔镜手术中以0.4μg/kg的右美托咪定辅助全身麻醉的整体效果较好,安全性较高。

Objective To analyze the anesthetic effect and safety of different doses of dexmedetomidine in patients undergoing laparoscopic surgery.Methods One hundred cases of patients undergoing laparoscopic surgery in our hospital were randomly divided into control group and observation group,with 50 cases in each group.Both groups were given dexmedetomidine intravenously,the dose of the control group was 0.8μg/kg,and dose of the observation group was 0.4μg/kg.The anesthetic effects were compared between the two groups.Results The orientation recovery time,PACU stay time and awakening time of the observation group were shorter than those of the control group,and the Riker sedation agitation score of the observation group was significantly lower than that of the control group(P<0.05).At 12 h after anesthesia,CD3+,CD4+and CD4+/CD8+in the two groups were lower than those before anesthesia,but those of the observation group were higher than the control group(P<0.05).At 30 min after operation and the end of the operation,the TcPO2 of the observation group was higher than that of the control group(P<0.05).The total incidence of adverse reactions and incidence of POCD in the observation group were lower than those in the control group(P<0.05).Conclusion In laparoscopic surgery,0.4μg/kg dexmedetomidine assisted general anesthesia has a better overall effect and higher safety.