尿酸水平与糖尿病患者颈动脉硬化相关性分析

Correlation Analysis of Uric Acid Level and Carotid Atherosclerosis in Diabetic Patients

目的探讨尿酸水平与糖尿病患者颈动脉硬化的关系。方法方便选取2018年5月-2019年9月在该院就诊的糖尿病患者60例,用彩色多普勒超声仪检测颈动脉,根据颈动脉是否有粥样硬化分为颈动脉硬化组和无颈动脉硬化组,每组30例。收集两组患者基线资料,检测其尿酸、总胆固醇、甘油三酯、低密度脂蛋白、糖化血红蛋白,分析各指标与糖尿病患者颈动脉硬化之间的相关性。结果颈动脉硬化组患者UA(409.5±185.5)mmol/L vs(364.0±129.0)mmol/L,TC(5.125±1.405)mmol/L vs(4.690±2.000)mmol/L,LDL-C(3.005±0.885)mmol/L vs(2.910±1.490)mmol/L,均高于无颈动脉硬化组患者,差异有统计学意义(t=3.276、3.969、2.153,P<0.05)。随着UA含量的增加,糖尿病患者颈动脉硬化的发生率也随之升高,差异有统计学意义(P<0.05)。Logistic回归分析显示年龄、尿酸、总胆固醇是引发糖尿病患者颈动脉硬化的危险因素(OR>1,P<0.05)。结论尿酸水平与糖尿病患者颈动脉硬化的发生有密切的关系,尿酸升高、年龄增加、总胆固醇升高是引发糖尿病患者颈动脉硬化的高危因素。

Objective To explore the relationship between uric acid level and carotid atherosclerosis in diabetic patients.Methods Convenient select 60 diabetic patients who were conrenient treated in the hospital from May 2018 to September 2019,use color Doppler ultrasound to detect carotid arteries,and divide them into carotid atherosclerosis group and no neck according to whether the carotid artery has atherosclerosis Atherosclerosis group,30 cases in each group.Collect baseline data of two groups of patients,detect their uric acid,total cholesterol,triglycerides,low-density lipoprotein,glycated hemoglobin,and analyze the correlation between each index and carotid atherosclerosis in diabetic patients.Results Age of patients in carotid atherosclerosis group(67±16)year vs(64±16)year,UA(409.5±185.5)mmol/L vs(364.0±129.0)mmol/L,TC(5.125±1.405)mmol/L vs(4.690±2.000)mmol/L,LDL-C(3.005±0.885)mmol/L vs(2.910±1.490)mmol/L,were higher than those without carotid atherosclerosis,the difference was statistically significant(t=3.276,3.969,2.153,P<0.05).With the increase of UA content,the incidence of carotid atherosclerosis in diabetic patients also increased(P<0.05).Logistic regression analysis showed that age,uric acid and total cholesterol were the risk factors for carotid atherosclerosis in patients with diabetes(OR>1,P<0.05).Conclusion Uric acid level is closely related to the occurrence of carotid arteriosclerosis in diabetic patients.Elevated uric acid,age,and total cholesterol are the high-risk factors that cause carotid atherosclerosis in diabetic patients.