低剂量索他洛尔与普罗帕酮治疗心律不齐的临床效果探讨

The Clinical Effect of Low-dose Sotalol and Propafenone on Arrhythmia

目的探究低剂量索他洛尔与普罗帕酮治疗心律不齐的临床疗效。方法单纯随机选取2018年4月-2019年5月该院室66例心律不齐患者进行该次研究,选用随机数字表法,将研究对象分为两组,对比组33例,研究组33例。对比组进行普罗帕酮治疗,研究组进行低剂量索他洛尔,分析两组的临床疗效、不良反应发生率以及QTd和QTdc数据。结果研究组显效23例、有效9例、无效1例,总有效率为96.97%,对比组显效18例、有效8例、无效7例,总有效率78.79%(χ^2=5.120,P=0.023);研究组的QTd值为(53.2±3.9)ms,对比组为(56.5±3.6)ms(t=3.571,P=0.000);研究组的QTdc值为(80.1±4.2)ms,对比组为(83.7±3.9)ms(t=3.654,P=0.000);研究组的临床治疗总有效率大于对比组,QTd、QTdc值改善优于对比组,差异有统计学意义(P<0.05);研究组头痛头晕1例、消化道病症2例、口干0例、乏力0例、其他1例,总发生率为12.12%,对比组头痛头晕1例、消化道病症0例、口干2例、乏力1例、其他2例,总发生率为18.18%(χ^2=0.471,P=0.492),不良反应发生率两组对比差异无统计学意义(P>0.05)。结论低剂量索他洛尔治疗心律不齐,能够良好地提升临床治疗效率,改善QTd和QTdc值,而产生的临床不良反应与普罗帕酮治疗差异无统计学意义,在临床的实用价值显著。

Objective To explore the clinical effect of low-dose sotalol and propafenone on arrhythmia.Methods From April 2018 to May 2019,a total of 66 patients with arrhythmia in the undergraduate department were simple and random selected for this study.The random number table method was used to divide the research subjects into two groups and 33 cases in the comparison group.33 patients in the study group were treated with Propatenone in the control group and low-dose sotalol in the study group.The clinical efficacy,incidence of adverse reactions,and QTd and QTdc data were analyzed in the two groups.Results 23 cases were markedly effective in the study group,9 cases were effective,1 case was invalid,the total effective rate was 96.97%,18 cases were markedly effective in the comparison group,8 cases were effective,7 cases were invalid,the total effective rate was 78.79%(χ^2=5.120,P=0.023);the QTd value of the study group was(53.2±3.9)ms,the comparison group was(56.5±3.6)ms(t=3.571,P=0.000);the QTdc value of the study group was(80.1±4.2)ms,the comparison group was(83.7±3.9)ms(t=3.654,P=0.000);the total effective rate of clinical treatment in the study group was greater than that in the comparison group,the iniprovement of QTd、Qidc was better than the comparison group comparison group.The difference was statistically significant(P<0.05);1 case of headache and dizziness in the study group,2 cases of gastrointestinal disorders,0 cases of dry mouth,0 cases of fatigue,1 other case,the total incidence rate was 12.12%,1 case of headache and dizziness in the control group,0 cases of gastrointestinal disorders,dry mouth In 2 case,1 case of fatigue,and 2 other cases,the total incidence rate was 18.18%(χ^2=0.471,P=0.492).The incidence of adverse reactions was not statistically significantly different between the two groups(P>0.05).Conclusion Low-dose sotalol can treat arrhythmia,improve the clinical treatment efficiency,and improve the QTd and QTdc values.The clinical adverse reactions produced are not significantly different from those of propafenone treatment,so the clinical practical value is significant.