他汀用于急性心肌梗死急诊PCI术后慢性心力衰竭患者的疗效

Efficacy of Statin in Patients with Chronic Heart Failure after Emergency PCI for Acute Myocardial Infarction

目的:探究急性心肌梗死急诊经冠状动脉介入(PCI)术后慢性心力衰竭患者应用他汀类药物的治疗效果,包括患者的外周血肿瘤坏死因子(TNF-α)、基质金属蛋白酶(MMP-2)、白细胞介素(IL-6)和患者心功能等指标变化。方法:从某院2015年10月~2018年5月接收并治疗的急性心肌梗死急诊PCI术后慢性心力衰竭患者中随机性抽取98例,并随机分为对照组和研究组,每组各49例,对照组采用常规治疗,研究组应用瑞舒伐他汀治疗,将抽取的98例急性心肌梗死急诊PCI术后慢性心力衰竭患者进行资料观察、实验室检查、炎性因子检查、心脏超声检查与步行实验,随访后观察各项指标变化情况。结果:两组抽取的急性心肌梗死急诊PCI术后慢性心力衰竭患者通过不同方法治疗后,结果显示,研究组患者通过应用他汀类药物治疗,其TNF-α/(pg/ml)、IL-6/(pg/ml)、MMP-2/(pg/ml)分别为(17.5±2.8)、(6.8±5.4)和(210.3±24.8),明显优于对照组常规治疗后其TNF-α/(pg/ml)、IL-6/(pg/ml)、MMP-2/(pg/ml)分别为(25.4±1.7)、(13.8±5.5)和(248.3±30.2),两组数据差异性较大(P<0.05),具有统计学研究价值。结论:针对急性心肌梗死急诊PCI术后慢性心力衰竭患者应用他汀类药物,尤其是瑞舒伐他汀进行治疗,可以起到较好的治疗效果,能够改善血脂等指标,值得在临床治疗中应用和推荐。

Objective:To explore the therapeutic effect of statins in patients with chronic heart failure after emergency percutaneous coronary intervention(PCI)for acute myocardial infarction,including changes of tumor necrosis factor(TNF-α),matrix metalloproteinase(MMP-2),interleukin(IL-6)and cardiac function.Methods:98 patients with chronic heart failure after emergency PCI for acute myocardial infarction treated in a hospital from October 2015 to May 2018 were selected and randomly divided into control group and study group,with 49 cases in each group.The control group was treated with routine therapy,while the study group was treated with rosuvastatin.The data observation,laboratory examination,inflammatory factor examination,echocardiography and walking test were carried out in 98 patients with chronic heart failure after emergency PCI for acute myocardial infarction,and the changes of various indicators were observed after follow-up.Results:After treatment,the results showed that the TNF-αlpha/(pg/ml),IL-6/(pg/ml),MMP-2/(pg/ml)in the study group were(17.5±2.8),(6.8±5.4)and(210.3±24.8),respectively,which were significantly better than those in the control group[(25.4±1.7),(13.8±5.5)and(248.3±30.2)].There were significant differences between the two groups,with statistical research value(P<0.05).Conclusion:Statins especially rosuvastatin,can be used to treat patients with chronic heart failure after emergency PCI for acute myocardial infarction,which can improve blood lipid and other indicators,and is worthy of application and recommendation in clinical treatment.