抗心律失常药物体内代谢及其临床影响因素

Metabolism of Antiarrhythmic Drugs and its Affecting Factors

药物代谢的研究在国内外受到广泛重视并取得了较大进展。抗心律失常药物作为临床上常用的品种，其体内代谢有一定的特点。通过对抗心律失常药在人体内代谢部位、代谢途径、代谢物活性及影响药物代谢主要因素的深入研究，有利于药物临床合理使用，提高疗效，减少药物不良反应，实现个体化治疗原则，同时可为药物发展提供新的方向和思路。本文综述了抗心律失常药物代谢的研究进展，并详细报道遗传因素、性别因素及药物间相互作用等对抗心律失常药物代谢的影响及其临床意义。

Drug metabolism is an important part of pharmacokinetics. It has been paid more attention in worldwide studies and great progress has been achieved. As normal clinical therapeutic agents, antiarrhythmic drugs have their special metabolism characters. By knowledge of the site, routes and mechanisms of antiarrhythmic drugs' metabolism, as well as the factors affecting these processes, it is possible to increase the rationalization of drug using, to decrease the side effects and to provide direction for new drug development as well. Based on published papers, this article has reviewed the metabolism of antiarrhythmic drugs, emphasizing on the affecting factors including genetics, sex and drug interaction.