肠道菌群代谢产物在鼠伤寒沙门菌感染中的作用研究进展

The role of gut microbiota metabolites in Salmonella enterica serovar Typhimurium infection: research progress

人和动物肠道内生存着多种多样的微生物群体,它们与宿主共同进化,对宿主的健康至关重要。肠道菌群可以发酵宿主难以消化的复杂碳水化合物,为宿主肠道细胞提供能量,同时其代谢产物对肠道病原菌沙门菌的感染产生着重要影响。正常情况下,肠道菌群代谢产物如丁酸与丙酸可以抑制沙门菌在肠道中的定植或者毒力基因的表达,而在肠道菌群受到扰乱时,其代谢的琥珀酸盐和1,2-丙二醇等物质却能促进沙门菌增殖。近年来,越来越多的研究揭示了肠道菌群代谢产物对沙门菌感染的影响。本综述通过总结近年来关于鼠伤寒沙门菌入侵时肠道菌群代谢产物改变的研究,综合阐述了肠道菌群代谢产物影响沙门菌感染的机制。

There are diverse microorganisms in the guts of human and animals,called gut microbiota.They co-evolve with their hosts,and play a key role in the health of the hosts.In detail,gut microbiota ferment complex carbohydrates that cannot be utilized by hosts and produce short chain fatty acids which are main energy source of epithelial cells,and have great effect on enteric pathogen infections.Under normal conditions,metabolites such as butyrate and propionate suppress the colonization and virulence of Salmonella in the gut.However,when the balance is disrupted,the metabolites like succinate and 1,2-propanediol can give Salmonella growth advantages.Recent studies have revealed how the metabolites of gut microbiota change and what′s the role they may play during Salmonella infection.We reviewed the effects the metabolites of gut microbiota have on Salmonella infection and the probable mechanism behind.