摘要
近年来,circRNAs因其在外泌体中稳定富集而被发现,也被称为外泌体环状RNAs(exo-circRNAs)。尽管它们在基因调控中的确切作用和机制尚不清楚,但随着研究的深入,exo-circRNAs作为人类疾病的新型生物标志物,可能成为疾病诊断和靶向治疗的新途径。该文将简要综述exo-circRNAs的分子机制和研究新进展,并探讨exo-circRNAs在人类疾病中的特殊作用。
In recent years,circRNAs,also known as exo-circRNAs,have been discovered for their stable enrichment in exosomes.Although the exact role and mechanism of exo-circRNAs in gene regulation is still unclear,with the development of research,exo-circRNAs,as a new biomarker of human diseases,may become a new approach for disease diagnosis and targeted therapy.This paper will briefly review the molecular mechanism and the latest findings of exo-circRNAs,and explore the special role of exo-circRNAs in human diseases.
作者
商安全(综述)
孙俊俊
谷晨峥
平伊丽
孙祖俊
李冬(审校)
SHANG Anquan;SUN Junjun;GU Chenzheng;PING Yili;SUN Zujun;LI Dong(Department of Clinical Laboratory,Tongji Hospital of Tongji University,Shanghai 200065,China;School of Medicine,Tongji University,Shanghai 200065,China;Department of Laboratory Medicine,the Sixth People′s Hospital of Yancheng,Yancheng,Jiangsu 224005,China)
出处
《国际检验医学杂志》
CAS
2020年第19期2410-2417,共8页
International Journal of Laboratory Medicine
基金
国家自然科学基金项目(81873975,81802084,81974314)
江苏省卫生健康委员会医学研究项目(Z2019039)。
