双源CT冠状动脉造影联合MMP-10和F-ABP检测对急性心肌梗死诊断价值效能研究

Diagnostic Value of CT Coronary Angiography Combined with MMP-10 and F-ABP in Myocardial Infarction

目的:探讨双源CT冠状动脉造影联合血清MMP-10、F-ABP水平检测(联合诊断)对新发急性心肌梗死(AMI)诊断效能。方法:选择我院心内科收治的62例AMI患者和60例非AMI心血管疾病患者,均行双源CT冠状动脉造影和血清MMP-10、F-ABP水平检测。以冠脉造影结果为准,分析双源CT冠状动脉造影联合血清MMP-10、F-ABP水平检测诊断AMI的效能。结果:病例组血清MMP-10、F-ABP水平高于对照组[(8.32±0.26)μg/L vs(5.95±0.39)μg/L、(8.59±2.34)μg/L vs(4.21±1.25)μg/L,P<0.05]。双源CT正确诊断AMI 56例,ROC分析双源CT、血清MMP-10、F-ABP、诊断AMI的曲线下面积(AUC)分别为0.910、0.843、0.772,双源CT诊断AMI的灵敏度为,特异度分别为90.32%、88.33%。MMP-10诊断AMI的灵敏度和特异度分别为79.03%、83.33%,F-ABP诊断AMI的灵敏度和特异度分别为83.87%和80.00%。联合诊断新发AMI的灵敏度、特异度分别为98.39%、100.00%。结论:双源CT冠状动脉造影、血清MMP-10、F-ABP水平检测均有一定诊断新发AMI效能,联合诊断更接近真实结果,准确性更高。

Objective:To explore the diagnostic efficacy of dual source CT coronary angiography combined with serum MMP-10 and F-ABP levels(combined diagnosis)for new acute myocardial infarction(AMI).Methods:62 patients with AMI and 60 patients with non AMI cardiovascular disease were enrolled in the Department of Cardiology of our hospital.The levels of MMP-10 and F-ABP were detected by dual source CT coronary angiography.Based on the results of coronary angiography,the diagnostic efficacy of dual source CT coronary angiography combined with serum MMP-10 and f-abp was analyzed.Results:the levels of MMP-10 and F-ABP in the case group were higher than those in the control group[(8.32±0.26)μg/L vs(5.95±0.39)μg/L,(8.59±2.34)μg/L vs(4.21±1.25)μg/L,P<0.05].56 cases of AMI were correctly diagnosed by dual source CT.ROC analysis showed that dual source CT,serum MMP-10,F-ABP and AUC were 0.910,0.843 and 0.772 respectively.The sensitivity and specificity of dual source CT were 90.32%and 88.33% respectively.The sensitivity and specificity of MMP-10 in the diagnosis of AMI were 79.03% and 83.33% respectively.The sensitivity and specificity of F-ABP in the diagnosis of AMI were 83.87% and 80.00% respectively.The sensitivity and specificity were 98.39% and 100.00%,respectively.Conclusion:dual source CT coronary angiography,serum MMP-10,F-ABP levels have certain diagnostic efficacy for new AMI,the combined diagnosis is closer to the real results,with higher accuracy.