新诊断糖尿病患者血清半乳糖凝集素-3水平及其相关因素分析

Serum galectin-3 level and related factors in newly-diagnosed diabetes

目的观察新诊断糖尿病患者的血清半乳糖凝集素-3(Gal-3)水平,并分析Gal-3的相关影响因素。方法以60例新诊断糖尿病患者(新诊断糖尿病组)和62例健康体检者(对照组)为研究对象,检测血清空腹血糖、糖化血红蛋白、Gal-3、空腹C肽、空腹胰岛素等指标水平,进一步分析Gal-3与年龄、血糖代谢指标等的相关性。结果新诊断糖尿病组血清Gal-3水平为3.99(1.92,6.06)ng/mL,高于对照组的3.38(1.92,4.84)ng/mL,差异有统计学意义(P<0.05)。Pearson相关分析显示,血清Gal-3水平与年龄、空腹血糖及糖化血红蛋白水平均呈正相关(P<0.05);多元回归分析显示,年龄、糖化血红蛋白是Gal-3的影响因素(P<0.05)。结论血清Gal-3表达水平与糖代谢指标具有相关性,提示Gal-3在糖代谢评估或糖尿病诊治中具有潜在的应用价值。

Objective To observe level of serum galectin-3(Gal-3)level in newly diagnosed diabetic patients and related factors.Methods A total of 60 newly diagnosed diabetic patients(newly diagnosed diabetic group)and 62 normal controls were enrolled.Fasting insulin,glycosylated hemoglobin,serum Gal-3,fasting C-peptide and fasting insulin were measured.The correlations between Gal-3 level and age as well as metabolism indexes of blood glucose were further analyzed.Results Serum Gal-3 level in the newly diagnosed diabetes group was significantly higher than that in the control group[3.99(1.92,6.06)ng/m L versus 3.38(1.92,4.84)ng/m L,P<0.05].Pearson correlation analysis showed that serum Gal-3 level was positively correlated with age fasting,blood glucose and glycosylated hemoglobin(P<0.05);multiple regression analysis showed that age and glycosylated hemoglobin were the influencing factors of Gal-3.Conclusion There was a correlation between serum Gal-3 expression level and metabolism indexes of blood glucose,suggesting potential value of Gal-3 in evaluation of glucose metabolism or diagnosis of diabetes mellitus.