左乙拉西坦与奥卡西平治疗成人部分性发作癫痫的疗效比较

Levetiracetam versus oxcarbazepine in the treatment of partial seizures in adults with epilepsy

目的比较左乙拉西坦、奥卡西平治疗成人部分性发作癫痫的临床效果。方法选取本院收治的142例成人部分性发作癫痫患者作为研究对象,采用电脑随机分组法分成2组,每组71例。对照组采用左乙拉西坦治疗,观察组采用奥卡西平治疗,比较2组患者的疗效、治疗前后脑电图变化和不良反应发生率。结果观察组总有效率为81.69%,对照组为69.01%,差异无统计学意义(P>0.05);治疗后,观察组θ频段相对功率为(30.76±6.84)%,高于对照组的(22.03±6.72)%,差异有统计学意义(P<0.05);观察组癫痫样放电(IEA)减少大于50%者比率为60.56%,对照组为54.93%,差异无统计学意义(P>0.05);观察组不良反应发生率为9.86%,对照组为12.68%,差异无统计学意义(P>0.05)。结论左乙拉西坦、奥卡西平治疗成人部分性发作癫痫均疗效确切,安全性良好,可明显抑制IEA,其中奥卡西平对脑电图活动的影响更大。

Objective To compare the efficacy of levetiracetam and oxcarbazepine in the treatment of partial seizures in adults with epilepsy.Methods A total of 142 adult patients with partial seizures in adults with epilepsy were randomly divided into two groups according to computer randomized method,with 71 cases in each group.The control group was treated with levetiracetam and the observation group was treated with oxcarbazepine.The curative effect,electroencephalogram changes and adverse reaction rate before and after treatment were compared between the two groups.Results The total effective rate was 81.69%in the observation group,and 69.01%in the control group,but there was no significant difference(P>0.05).After treatment,the relative power ofθfrequency band in the observation group was(30.76±6.84)%,which was significantly higher than(22.03±6.72)%in the control group(P<0.05).The ratio of patients with interictal epileptiform discharges(IEA)reducing more than 50%was 60.56%in the observation group,and was 54.93%in the control group,and there was no significant difference(P>0.05).The incidence of adverse reactions was9.86%in the observation group,and 12.68%in the control group,but there was no significant difference(P>0.05).Conclusion Levetiracetam and oxcarbazepine are effective and safe in the treatment of partial seizures in adults,and can significantly inhibit IEA,but oxacepine has greater influence on activity of electroencephalogram.