补肾活血通络方定向透药治疗肾虚血瘀型腰痛研究

Directional penetration of Tonifying Kidney and Activating Blood Circulation Recipe in the treatment of low back pain differentiated as kidney deficiency and blood stasis type

目的观察补肾活血通络方定向透药法治疗肾虚血瘀型慢性腰痛的临床疗效。方法将74例肾虚血瘀型慢性腰痛患者随机分为对照组与观察组,每组37例。对照组采用塞来昔布与甲钴胺口服治疗,观察组采用补肾活血通络方定向透药法治疗。比较2组患者治疗前后改良日本骨科学会下腰痛评分法(M-JOA)评分、Oswestry功能障碍指数(ODI)评分、中医证候积分、炎症细胞因子水平,并观察2组治疗效果。结果治疗后,2组M-JOA评分和ODI评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,2组各项中医证候积分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,2组白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)和白细胞介素-17(IL-17)水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为94.59%,高于对照组的75.68%,差异有统计学意义(P<0.05)。结论补肾活血通络方定向透药法治疗肾虚血瘀型慢性腰痛疗效可靠,能改善患者症状,缓解腰痛,有效降低炎症细胞因子水平。

Objective To explore clinical effect of directional penetration of Tonifying Kidney and Activating Blood Circulation Recipe in the treatment of chronic low back pain differentiated as kidney deficiency and blood stasis type.Methods A total of 74 cases with chronic low back pain differentiated as kidney deficiency and blood stasis type were divided into control group and observation group.The control group(n=37)was orally taken celecoxib and mecobalamine,while the observation group(n=37)was treated with directional penetration of Tonifying Kidney and Activating Blood Circulation Recipe.The low back pain score of modified Japanese Orthopaedic Society(M-JOA),Oswestry Disability Index(ODI)score,traditional Chinese medicine syndrome score,inflammatory cytokines levels were compared between the two groups before and after treatment,and therapeutic effect of two groups was observed.Results The M-JOA score and ODI score of the two groups decreased after treatment,and the observation group was significantly lower than the control group(P<0.05);after treatment,the item score of TCM syndrome in the two groups was decreased,and the observation group was significantly lower than the control group(P<0.05).After treatment,the levels of interleukin-1(IL-1),interleukin-6(IL-6)and interleukin-17(IL-17)in the two groups were all lower than those before treatment,and their levels in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate was 94.59%in the observation group and 75.68%in the control group,there was a significant difference between the two groups(P<0.05).Conclusion The clinical effect of Tonifying Kidney and Activating Blood Circulation Recipe is reliable in the treatment of chronic low back pain differentiated as kidney deficiency and blood stasis type.It can help patients to improve symptoms,relieve low back pain and effectively reduce the level of inflammatory cytokines.