腺苷三磷酸结合盒转运蛋白家族成员乳腺癌耐药蛋白基因多态性对药代动力学影响的研究现状

Research status of the effect of adenosine triphosphate binding cassette super family G member 2 gene polymorphism on pharmacokinetics

腺苷三磷酸结合盒转运蛋白家族成员乳腺癌耐药蛋白(ABCG2)参与多种药物的吸收、分布和消除,是涉及药物肠道吸收或渗透最重要的外排转运蛋白之一,具有多功能外排泵的作用。ABCG2基因单核苷酸多态性与多种药物的药代动力学相关。本文就ABCG2基因单核苷酸多态性与药物药代动力学关系的最新研究进行综述。

Adenosine triphosphate binding cassette superfamily G member 2(ABCG2)has the function of multifunctional efflux pump.It is one of the most important efflux transporters involved in intestinal absorption or permeation of drugs and relevant to the absorption,distribution and elimination of many drugs.Single nucleotide polymorphism of the ABCG2 gene is related to the pharmacokinetics of many drugs.This paper reviews the latest research on the relationship between single nucleotide polymorphism of the ABCG2 gene and pharmacokinetics.