米诺环素治疗重度玫瑰痤疮眼型的临床疗效观察

Clinical effect of minocycline in treating severe ocularrosacea

目的探讨米诺环素治疗重度玫瑰痤疮眼型的疗效。方法2016年4月至2017年12月在南京医科大学眼科医院角膜病门诊收集重度玫瑰痤疮眼型患者23例[男8例,女15例,年龄13~26(19.52±0.89)岁]。治疗8周,前2周口服米诺环素,每天100 mg,后6周口服米诺环素,每天50 mg。记录患者治疗前后眼部、全身皮肤情况和最佳矫正视力,比较治疗前后视力及眼部和全身皮肤炎症程度分级评价疗效。结果米诺环素治疗重度玫瑰痤疮眼型2周后,14例患者眼部情况改善、皮炎消退,有效率60.87%;治疗8周后23例有效率100%。治疗期间未见药物不良反应。治疗前Log MAR视力0.20±0.09,治疗后8周Log MAR视力0.14±0.07,治疗前后比较,差异有统计学意义(t=4.04,P<0.05)。患者最长随访18个月未见复发。结论米诺环素治疗重度玫瑰痤疮眼型安全、有效,并能控制复发。

Objective To evaluate the effect of minocycline on severe ocular rosacea.Methods Twenty-three patients with severe ocular rosacea were recruited and received 8 weeks treatment.Oral minocycline 100 mg was given daily for the first 2 weeks,and 50 mg daily minocycline daily for the next 6 weeks.The best corrected visual acuity and the eye and body skin conditions before and after treatment were recorded.The visual acuity and the degree of skin and body inflammation were compared before and after treatment to evaluate the efficacy.Results After 2 weeks of minocycline treatment for severe rosacea eye type,14 patients had improved eye conditions and dermatitis subsided,with an effective rate of 60.87%;23 patients had an effective rate of 100%after 8 weeks of treatment.No adverse drug reactions were seen during treatment.The visual acuity before treatment was 0.20±0.09,and the visual acuity was 0.14±0.078 weeks after treatment.The patients were followed up for 18 months without recurrence.Conclusions Minocycline is safe and effective in treating severe ocular rosacea and can control recurrence.