氧化应激与急性胰腺炎的研究进展

Research progress of oxidative stress and acute pancreatitis

急性胰腺炎(AP)是常见的临床急腹症,常并发胰腺坏死、假性囊肿和腹腔脓肿等局部并发症,并可引发全身炎症反应综合征及多器官功能障碍综合征,病情凶险,治疗棘手,预后差。尽管关于AP的发病机制已取得重大进展,但具体机制仍不明确。在过去的几十年中,许多研究都强调了氧化应激在急性炎症反应中的作用,本文通过介绍氧化应激打破细胞Ca^2+平衡、参与转录因子的活化和炎症介质的过度释放,阐明了氧化应激在AP的发生、发展中扮演的角色,并介绍抗氧化剂辅助治疗在AP治疗中的应用。

Acute pancreatitis(AP)is a common clinical acute abdominal disease,usually with local complications such as pancreatic necrosis,pseudocysts,and abdominal abscesses,as well as systemic inflammatory response syndrome and multiple organ dysfunction syndrome.It is dangerous,difficult to treat,and the prognosis is poor.Although significant progress has been made on the pathogenesis of AP,its specific mechanism is still unclear.In the past few decades,many studies have emphasized the role of oxidative stress in acute inflammatory response.This article clarified the role of oxidative stress in the occurrence and development of AP by introducing oxidative stress to break the cellular Ca^2+balance,participate in the stimulation of transcription factor activation and excessive release of inflammatory mediators and introduces the application of antioxidant adjuvant therapy in the treatment of AP.