阿司匹林和低分子肝素治疗习惯性流产临床疗效评价

Evaluation of the Clinical Efficacy of Aspirin and Low Molecular Weight Heparin in the Treatment of Habitual Abortion

目的研究阿司匹林和低分子肝素运用在习惯性流产患者中的临床疗效。方法研究对象选取2018年5月-2019年5月该院收治的94例习惯性流产患者,使用随机数字表法进行分组,即对照组(47例,予以阿司匹林治疗)与实验组(47例,予以阿司匹林+低分子肝素治疗),比较两组指标改善情况、临床疗效、妊娠结局、不良反应情况。结果①实验组分娩出血量少于对照组(t=17.875,P=0.001),且实验组流产孕周与分娩周期均多于对照组(t=18.930、15.740,P=0.001);②实验组总有效率为97.87%,高于对照组85.11%(χ^2=4.919,P=0.027);③实验组足月产率74.47%、活产率97.87%均高于对照组51.06%、85.11%(χ^2=5.508、4.919,P=0.019、0.027),且实验组流产率2.13%低于对照组14.89%(χ^2=4.919,P=0.027);④实验组2例不良反应,不良反应发生率是4.26%,对照组8例不良反应,不良反应发生率是17.02%(χ^2=4.029,P=0.045)。结论为习惯性流产患者提供阿司匹林与低分子肝素联合治疗,疗效显著,安全可靠,且能改善妊娠结局。

Objective To study the clinical efficacy of aspirin and low molecular weight heparin in patients with habitual abortion.Meth-ods The study subjects selected 94 patients with habitual abortion admitted to our hospital from May 2018 to May 2019.They were di-vided into groups using a random number table,namely the control group(47 cases,treated with aspirin)and the experimental group(47 cases,treated with aspirin+low molecular heparin),and compared the improvement of the two groups of indicators,clinical effi-cacy,pregnancy outcome,and adverse reactions.Results 1.The amount of bleeding during labor in the experimental group was less than that in the control group(t=17.875,P=0.001),and the gestational week and delivery period of abortion in the experimental group were more than those in the control group(t=18.930,15.740,P=0.001);2.Experiment The total effective rate of the group was 97.87%,which was higher than 85.11%of the control group(χ^2=4.919,P=0.027);3.The full-term birth rate of the experimental group was74.47%and the live birth rate of 97.87%were higher than those of the control group by 51.06%and 85.11%(χ^2=5.508,4.919,P=0.019,0.027),and the abortion rate of the experimental group was 2.13%lower than that of the control group 14.89%(χ^2=4.919,P=0.027);4.There were 2 adverse reactions in the experimental group.The incidence of adverse reactions was 4.26%,8 cases of adverse reactions in the control group,the incidence of adverse reactions was 17.02%(χ^2=4.029,P=0.045).Conclusion The combination therapy of aspirin and low molecular weight heparin for patients with habitual abortion has obvious curative effect,safety and reliability,and can improve pregnancy outcome,so it is worthy of clinical promotion.