缬沙坦联合美托洛尔对非杓型高血压患者血压及心率的节律影响

The Effect of Valsartan Combined with Metoprolol on Blood Pressure and Heart Rate Rhythm in Patients with Non-dipper Hypertension

目的探讨缬沙坦联合美托洛尔对非杓型高血压患者血压及心率节律的影响。方法选择山东良庄矿业有限公司医院2018年1月-2019年4月收治的104例非杓型高血压患者,随机分为对照组及观察组,对照组给予缬沙坦降压,观察组给予缬沙坦联合美托洛尔控制降压,比较两组患者血压控制情况,非杓型血压及非杓型心率恢复情况。结果白昼收缩压(dSBP)、夜间收缩压(nSBP)、白昼舒张压(dDBP)、夜间舒张压(nDBP)、白昼心率(dHR)及夜间心率(nHR)两组治疗前差异无统计学意义(P>0.05),dSBP、nSBP、dDBP、nDBP、dHR、nHR对照组治疗后为(127.6±8.4)mmHg、(118.3±7.6)mmHg、(87.4±6.8)mmHg、(79.3±7.1)mmHg、(83.5±5.6)次/min、(73.8±6.2)次/min,观察组治疗后为(119.3±7.1)mmHg、(112.5±6.4)mmHg、(82.1±5.6)mmHg、(73.3±5.6)mmHg、(77.4±6.4)次/min、(67.3±5.7)次/min,治疗后观察组dSBP、nSBP、dDBP、nDBP、dHR及nHR均低于对照组(P<0.05),杓型血压及杓型心率对照组治疗前分别为0.0%、40.4%,治疗后分别为63.5%、78.8%,观察组治疗前分别为0.0%、42.3%,治疗后分别为92.3%、94.2%,治疗前两组杓型血压及杓型心率比例差异无统计学意义(P>0.05),治疗后观察组杓型血压及杓型心率比例高于对照组(P<0.05)。结论缬沙坦联合美托洛尔能够改善非杓型高血压的血压控制效果,恢复血压及心律的正常昼夜节律,具有较好的临床效果。

Objective To investigate the effect of valsartan combined with metoprolol on blood pressure and heart rate rhythm in patients with non-dipper hypertension.Methods A total of 104 patients with non-dipper hypertension admitted to Shandong Liangzhuang Min-ing Co.,Ltd.Hospital from January 2018 to April 2019 were randomly divided into control group and observation group.The control group was given valsartan to lower blood pressure,and the observation group was given Valsartan combined with metoprolol to control blood pressure,compare the control of blood pressure,non-dipper blood pressure and non-dipper heart rate recovery between the two groups.Results Day systolic blood pressure(dSBP),night systolic blood pressure(nSBP),day diastolic blood pressure(dDBP),night diastolic blood pressure(nDBP),day heart rate(dHR)and night heart rate(nHR)had no significant difference before treatment(P>0.05),dSBP,nSBP,dDBP,nDBP,dHR,nHR control group after treatment are(127.6±8.4)mmHg,(118.3±7.6)mmHg,(87.4±6.8)mmHg,(79.3±7.1)mmHg,(83.5±5.6)times/min,(73.8±6.2)times/min,after treatment observation group(119.3±7.1)mmHg,(112.5±6.4)mmHg,(82.1±5.6)mmHg,(73.3±5.6)mmHg,(77.4±6.4)times/min,(67.3±5.7)times/mini,dSBP,nSBP,dDBP,nDBP,dHR and nHR in the observation group after treatment were lower than those in the control group(P>0.05),dipper blood pressure and dipper heart rate control group They were 0.0%and 40.4%before treatment,63.5%and 78.8%after treatment,0.0%and 42.3%before treatment in the observation group,and 92.3%and 94.2%after treatment.There was no significant difference in the ratio of dipper heart rate(P>0.05).After treatment,the ratio of dipper blood pressure and dipper heart rate in the observation group was higher than that of the control group(P>0.05).Conclusion Valsartan combined with metoprolol can improve the blood pressure control effect of non-dipper hypertension,restore the normal circadian rhythm of blood pressure and heart rhythm,and has a good clinical effect.