高危型HPV感染与宫颈癌前病变、宫颈癌的关系分析

Analysis of the relationship between high-risk HPV infection and cervical precancerous lesions and cervical cancer

目的分析高危型人乳头瘤病毒(HPV)感染与宫颈癌前病变、宫颈癌的关系。方法回顾性分析2018年2月~2020年1月在本院进行宫颈癌前病变或宫颈癌筛查的120例患者的临床资料,首先予以患者行HPV与液基薄层细胞(TCT)检查,再转诊阴道镜,并行宫颈活检术,随后根据活检检查结果将患者分为对照组(健康组)、观察组A组(宫颈癌前病变患者)与观察组B组(宫颈癌患者)。结果120例患者经筛查,其中,健康43例,宫颈癌前病变52例,宫颈癌25例。回顾患者的检查资料,观察A组(51.92%)与观察B组(88.00%)的HPV阳性检出率明显高于对照组(20.93%),且观察B组的阳性检出率也高于观察A组,差异有统计学意义(P<0.05);58例高危型HPV感染阳性患者中,HPV16共29例,HPV18共10例,HPV33共7例,HPV52共7例,HPV58共4例,其他共1例。结论高危型HPV感染会增加宫颈癌前病变、宫颈癌的发生风险,尤其是HPV16型感染。

Objective To analyze the relationship between high-risk human papillomavirus(HPV)infection and cervical precancerous lesions and cervical cancer.Methods The clinical data of 120 patients who underwent cervical precancerous lesions or cervical cancer screening admitted to our hospital from February 2018 to January 2020 were retrospectively analyzed.The patients were first examined by HPV and fluid-based thin-preparation cytologic test(TCT),then referred to colposcopy and underwent cervical biopsy.The patients were then divided into the control group(healthy group),the observation group A(cervical precancerous lesions patients)and the observation group B(cervical cancer patients)according to the biopsy results.Results 120 patients were screened,of which 43 were healthy,52 with precervical cancer and 25 with cervical cancer.Reviewing the examination data of patients,the positive detection rate of HPV in the observation group A(51.92%)and the observation group B(88.00%)was significantly higher than that in the control group(20.93%),and the positive detection rate in observation group B was also higher than that in the observation group A,and the difference was statistically significant(P<0.05).Of the 58 high-risk HPV positive patients,29 were HPV16,10 were HPV18,7 were HPV33,7 were HPV52,4 were HPV58,and 1 was other.Conclusion High-risk HPV infection will increase the risk of cervical precancerous lesions and cervical cancer,especially HPV16 infection.