盐酸纳洛酮联合BiPAP呼吸机治疗慢性阻塞性肺疾病急性发作并肺性脑病

Naloxone Hydrochloride Combined With BiPAP Ventilator in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Pulmonary Encephalopathy

目的分析慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)急性发作伴肺性脑病患者联合应用无创双水平正压通气(bi-level positive airway pressure,BiPAP)和盐酸纳洛酮疗法的临床效果。方法择选2018年1月—2019年11月在本院接受治疗的78例慢性阻塞性肺疾病急性发作伴肺性脑病患者为对象,经抓阄法分成对照组(39例)、试验组(39例);对照组采取无创双水平正压通气疗法,试验组基于对照组疗法另行盐酸纳洛酮疗法,比较两组治疗后的动脉血气指标以及总有效率。结果治疗前两组动脉血气指标比较差异无统计学意义(P> 0.05),治疗后试验组的血pH、PaO2高于对照组,PaCO2低于对照组,组间比较差异有统计学意义(P <0.05);试验组治疗总有效率为87.18%,高于对照组的66.67%,组间比较差异有统计学意义(P <0.05)。结论慢阻肺急性发作伴肺性脑病者联合应用无创双水平正压通气及盐酸纳洛酮疗法,可以改善患者的动脉血气指标,有利于患者获取更好的治疗效果。

Objective To analyze the clinical effects of non-invasive bilevel positive airway pressure(BiPAP)and naloxone hydrochloride therapy in patients with acute onset of chronic obstructive pulmonary disease(COPD)and pulmonary encephalopathy.Methods A total of 78 patients with COPD with acute exacerbations and pulmonary encephalopathy who were treated in our hospital from January 2018 to November 2019 were selected.They were divided into the control group(39 cases)and the experimental group(39 cases)by the method of grasping.The control group was treated with non-invasive bi-level positive airway pressure,and the experimental group was treated with naloxone hydrochloride based on the control group.The arterial blood gas index and the total effective rate were compared between the two groups.Results The arterial blood gas indicators of the two groups has no statistically significant(P>0.05).After treatment,the blood pH and PaO2 of the experimental group were higher than those of the control group,and PaCO2 was lower than that of the control group,the differences between the two groups were statistically significant(P<0.05).The total effective rate was 87.18%,which was higher than the control group by 66.67%,and the difference between the two groups was statistically significant(P<0.05).Conclusion The combined application of non-invasive positive pressure ventilation and naloxone hydrochloride therapy in patients with acute obstructive pulmonary disease and pulmonary encephalopathy can improve the arterial blood gas index of patients and help patients to obtain better treatment results.